Feng Yunxia, Li Yuan, Chen Shuo, Hu Na, Liao Dan
Department of Nephrology, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, China.
Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, College of Anesthesiology, Zunyi Medical University, Zunyi, China.
Front Nutr. 2024 Dec 4;11:1469844. doi: 10.3389/fnut.2024.1469844. eCollection 2024.
The association between serum vitamin A (VA) levels and outcomes in chronic kidney disease (CKD) patients remains unclear.
This was a population-based cohort study. CKD participants from the National Health and Nutrition Examination Survey (NHANES) database were included for analysis. The primary outcome was all-cause mortality. Person correlation analysis and Cox regression models were used to assess the relation between serum VA levels and all-cause mortality among individuals with CKD.
There were 689 participants included in this study. The serum VA level was 2.45 ± 1.06 μmol/L. The overall mortality was 43.69%. The participants in the nonsurvival group had higher serum VA levels than those in the survival group (2.18 ± 0.82 vs. 2.78 ± 1.24 μmol/L, < 0.01). Serum VA concentrations were positively correlated with serum creatinine levels (r = 0.56, < 0.01) and urea nitrogen (r = 0.58, < 0.01) but negatively correlated with eGFR (r = -0.56, < 0.01). The serum VA level was independently related to all-cause mortality (hazard ratio (HR) = 1.15, [95% CI: 1.01-1.31], = 0.03). The Kaplan-Meier survival analysis suggested that the survival probability was lower in participants with serum VA levels exceeding 2.09 μmol/L than in participants with serum VA levels below 2.09 μmol/L ( < 0.0001).
A high serum VA was independently related to all-cause mortality in CKD patients. VA requirements for patients with CKD is worth studies in the future.
慢性肾脏病（CKD）患者血清维生素A（VA）水平与预后之间的关联仍不明确。
这是一项基于人群的队列研究。纳入了来自国家健康与营养检查调查（NHANES）数据库的CKD参与者进行分析。主要结局是全因死亡率。采用Person相关分析和Cox回归模型评估CKD个体血清VA水平与全因死亡率之间的关系。
本研究共纳入689名参与者。血清VA水平为2.45±1.06μmol/L。总死亡率为43.69%。非存活组参与者血清VA水平高于存活组（2.18±0.82 vs. 2.78±1.24μmol/L，P<0.01）。血清VA浓度与血清肌酐水平呈正相关（r=0.56，P<0.01），与尿素氮呈正相关（r=0.58，P<0.01），但与估算肾小球滤过率（eGFR）呈负相关（r=-0.56，P<0.01）。血清VA水平与全因死亡率独立相关（风险比（HR）=1.15，[95%置信区间：1.01-1.31]，P=0.03）。Kaplan-Meier生存分析表明，血清VA水平超过2.09μmol/L的参与者的生存概率低于血清VA水平低于2.09μmol/L的参与者（P<0.0001）。
高血清VA与CKD患者的全因死亡率独立相关。CKD患者的VA需求值得未来研究。
