与表型年龄加速相关的新型基因位点——中国江苏省常州市，2012 - 2019年

Novel Genetic Loci Associated with PhenoAge Acceleration - Changzhou City, Jiangsu Province, China, 2012-2019.

作者信息

Wang Yifan, Jiang Yue, Wang Hui, Liang Shuang, Sambou Muhammed Lamin, Wang Mei, Yang Meiqi, Salimata Yakubu, Xu Feifei, Li Chenjie, Wang Xiao, Yang Junpeng, Zhu Meng, Wang Cheng, Jin Guangfu, Ma Hongxia, Yi Honggang, Shen Hongbing, Dai Juncheng

机构信息

Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing City, Jiangsu Province, China.

State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing City, Jiangsu Province, China.

出版信息

China CDC Wkly. 2024 Dec 6;6(49):1294-1298. doi: 10.46234/ccdcw2024.258.

DOI:10.46234/ccdcw2024.258

PMID:39698482

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11649982/

Abstract

WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: China is rapidly encountering population aging, yet studies on aging are limited by the traditional aging measure: chronological age, particularly in the field of genomics. Several promising aging measures have been proposed, but they lack comparative evaluation.

WHAT IS ADDED BY THIS REPORT?: PhenoAge was identified as a measure of aging that demonstrated greater applicability in contemporary populations. Based on this, several novel genetic variants were found to enhance the predictive accuracy of aging.

WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: These findings might provide new insights into aging and facilitate the development of a practical screening program based on PhenoAge, which aims to promote healthy aging in China.

摘要

关于该主题已知的信息有哪些？：中国正迅速面临人口老龄化问题，但衰老研究受到传统衰老衡量指标——实足年龄的限制，尤其是在基因组学领域。已经提出了几种有前景的衰老衡量指标，但它们缺乏比较评估。

本报告补充了哪些内容？：PhenoAge被确定为一种衰老衡量指标，在当代人群中显示出更大的适用性。基于此，发现了几种新的基因变异，可提高衰老预测的准确性。

对公共卫生实践有何启示？：这些发现可能为衰老研究提供新的见解，并促进基于PhenoAge的实用筛查项目的开发，该项目旨在促进中国的健康老龄化。