Department of Neurology, Chengdu Seventh People's Hospital, Chengdu, China.
General Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China.
Front Public Health. 2024 Oct 30;12:1423016. doi: 10.3389/fpubh.2024.1423016. eCollection 2024.
Cardiometabolic multimorbidity (CMM) and aging are increasing public health concerns. This prospective study used UK Biobank cohort to investigate the relationship between biological aging and the trajectory of CMM to dementia and mortality.
CMM is the coexistence of at least two cardiometabolic diseases (CMD), including stroke, ischemic heart disease, and diabetes. Biological age was calculated using the KDM-BA and PhenoAge algorithms. Accelerated aging indicated biological age advances more rapidly than chronological age.
The study included 415,147 individuals with an average age of 56.5 years. During the average 11-year follow-up period, CMD-free individuals with accelerated aging had a significantly greater risk of CMD (KDM-BA, HR 1.456; PhenoAge, HR 1.404), CMM (KDM-BA, HR 1.952; PhenoAge, HR 1.738), dementia (KDM-BA, HR 1.243; PhenoAge, HR 1.212), and mortality (KDM-BA, HR 1.821; PhenoAge, HR 2.047) in fully-adjusted Cox regression models ( < 0.05 for all). Accelerated aging had adjusted HRs of 1.489 (KDM-BA) and 1.488 (PhenoAge) for CMM, 1.434 (KDM-BA) and 1.514 (PhenoAge) for dementia, and 1.943 (KDM-BA) and 2.239 (PhenoAge) for mortality in participants with CMD at baseline ( < 0.05 for all). CMM significantly mediated accelerated aging's indirect effects on dementia by 13.7% (KDM-BA, HR) and 21.6% (PhenoAge); those on mortality were 4.7% (KDM-BA) and 5.2% (PhenoAge). The population attributable-risk of Life's Essential 8 score (≥80 vs. <80) were 0.79 and 0.43 for KDM-BA and PhenoAge accelerated aging, respectively.
Biological aging involves the entire trajectory of CMM from a CMD-free state to CMD, to CMM, and ultimately to dementia and death. Life's Essential 8 may be a potential target to counter age acceleration.
心脏代谢性多种疾病（CMM）和衰老都是日益严重的公共卫生问题。本前瞻性研究使用英国生物库队列，旨在调查生物年龄与 CMM 向痴呆和死亡的轨迹之间的关系。
CMM 是指至少存在两种心脏代谢疾病（CMD），包括中风、缺血性心脏病和糖尿病。使用 KDM-BA 和 PhenoAge 算法计算生物年龄。加速衰老表示生物年龄比实际年龄进展得更快。
本研究纳入了 415147 名平均年龄为 56.5 岁的个体。在平均 11 年的随访期间，无 CMD 的加速衰老个体发生 CMD（KDM-BA，HR 1.456；PhenoAge，HR 1.404）、CMM（KDM-BA，HR 1.952；PhenoAge，HR 1.738）、痴呆（KDM-BA，HR 1.243；PhenoAge，HR 1.212）和死亡（KDM-BA，HR 1.821；PhenoAge，HR 2.047）的风险显著增加，在完全调整的 Cox 回归模型中（所有 P<0.05）。在基线存在 CMD 的参与者中，加速衰老对 CMM 的调整 HR 为 1.489（KDM-BA）和 1.488（PhenoAge），对痴呆的调整 HR 为 1.434（KDM-BA）和 1.514（PhenoAge），对死亡率的调整 HR 为 1.943（KDM-BA）和 2.239（PhenoAge）（所有 P<0.05）。CMM 显著介导了加速衰老对痴呆的间接影响（KDM-BA，HR）为 13.7%和 21.6%（PhenoAge）；对死亡率的间接影响分别为 4.7%（KDM-BA）和 5.2%（PhenoAge）。Life's essential 8 评分（≥80 与<80）的人群归因风险分别为 KDM-BA 和 PhenoAge 加速衰老的 0.79 和 0.43。
生物衰老涉及从无 CMD 状态到 CMD、CMM，最终到痴呆和死亡的整个 CMM 轨迹。Life's essential 8 可能是对抗衰老加速的潜在目标。
