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血清来源的环状RNA诊断面板的鉴定及其在丙型肝炎病毒相关肝癌中的调控机制：一项横断面研究

Identification of Serum-Derived CricRNA Diagnostic Panel and Revealing Their Regulatory Mechanisms in HCV-HCC: A Cross-Sectional Study.

作者信息

Ishaq Yasmeen, Rauff Bisma, Alzahrani Badr, Javed Hassnain, Ikram Aqsa

机构信息

Institute of Molecular Biology and Biotechnology (IMBB) University of Lahore (UOL) Lahore Pakistan.

Department of Biomedical Engineering UET Lahore, Narowal campus Narowal Pakistan.

出版信息

Health Sci Rep. 2024 Dec 17;7(12):e70282. doi: 10.1002/hsr2.70282. eCollection 2024 Dec.

DOI:10.1002/hsr2.70282
PMID:39698527
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11652392/
Abstract

AIMS AND OBJECTIVES

Hepatitis C virus (HCV) infection is a significant risk factor for the development of hepatocellular carcinoma (HCC). Serum-derived circular RNAs (circRNAs) play several crucial roles in HCV and HCC. They represent a promising area of research for improving the diagnosis and understanding the mechanisms of HCV-HCC. This study aims to identify a serum-derived circular RNA (circRNA) diagnostic panel for HCV-HCC and to elucidate the regulatory mechanisms underlying their role in cancer progression.

METHODS

In this study, data mining and in silico analysis were conducted to identify the role of circular RNAs (hsa_circ_0003288, circ-RNF13, hsa_circ_0004277, circANRIL, circUHRF1, hsa_circ_103047) and their associated biomarkers (IL-6 and NF-κB) in HCV-HCC pathogenesis. Additionally, RT-PCR was performed to assess their expression levels across different study groups (G0 = control, G1 = HCV, G2 = HCC, and G3 = HCV-induced HCC).

RESULTS

The expression levels of circular RNAs, including hsa_circ_0003288, circ-RNF13, hsa_circ_0004277, circANRIL, circUHRF1, and hsa_circ_103047, as well as the biomarkers IL-6 and NF-κB, were significantly elevated in the G3 group compared to the G0 group. ROC analysis also revealed significantly different expression rates for G3 group and G0 group.

CONCLUSION

The data revealed that cricRNAs panel (hsa_circ_0003288, circ-RNF13, circANRIL, circUHRF1, and hsa_circ_103047) could serve as a diagnostic biomarker and therapeutic target for HCV-induced HCC.

摘要

目的与目标

丙型肝炎病毒（HCV）感染是肝细胞癌（HCC）发生发展的一个重要危险因素。血清来源的环状RNA（circRNA）在HCV和HCC中发挥着多种关键作用。它们是改善HCV-HCC诊断及理解其机制的一个很有前景的研究领域。本研究旨在确定一种用于HCV-HCC的血清来源环状RNA（circRNA）诊断标志物组合，并阐明其在癌症进展中作用的调控机制。

方法

在本研究中，进行了数据挖掘和计算机分析，以确定环状RNA（hsa_circ_0003288、circ-RNF13、hsa_circ_0004277、circANRIL、circUHRF1、hsa_circ_103047）及其相关生物标志物（IL-6和NF-κB）在HCV-HCC发病机制中的作用。此外，进行逆转录聚合酶链反应（RT-PCR）以评估它们在不同研究组（G0 = 对照组，G1 = HCV组，G2 = HCC组，G3 = HCV诱导的HCC组）中的表达水平。

结果

与G0组相比，G3组中包括hsa_circ_0003288、circ-RNF13、hsa_circ_0004277、circANRIL、circUHRF1和hsa_circ_103047在内的环状RNA以及生物标志物IL-6和NF-κB的表达水平显著升高。ROC分析还显示G3组和G0组的表达率有显著差异。

结论

数据表明，环状RNA组合（hsa_circ_0003288、circ-RNF13、circANRIL、circUHRF1和hsa_circ_103047）可作为HCV诱导的HCC的诊断生物标志物和治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7969/11652392/cbd7c3a2c70a/HSR2-7-e70282-g001.jpg
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