Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Chronic Inflammatory Diseases, Tehran University of Medical Sciences, Tehran, Iran.
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran; Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Pathol Res Pract. 2024 Sep;261:155488. doi: 10.1016/j.prp.2024.155488. Epub 2024 Jul 25.
P53 tumor suppressor is a major regulator of various cellular processes and functions. It has been reported that mutation or inactivation of p53 plays a crucial role in tumorigenesis in different types of cancers. Circular RNAs (circRNAs) are single-stranded non-coding RNAs that have significant post-transcriptional effects on the regulation of gene expression in various ways. These molecules can alter the expression and function of multiple genes and proteins. In the present study, we aimed to review circRNAs that regulate the expression, function, and stability of p53 and the possible interactions between these molecules and p53. Considering the importance of p53 in cancer and the network between p53 and circRNAs, future clinical trials targeting these circRNAs as therapeutic agents deserve worthy of attention.
P53 肿瘤抑制因子是各种细胞过程和功能的主要调节剂。据报道，p53 的突变或失活在不同类型癌症的肿瘤发生中起着关键作用。环状 RNA（circRNA）是单链非编码 RNA，通过多种方式对基因表达的转录后调控具有重要影响。这些分子可以改变多个基因和蛋白质的表达和功能。在本研究中，我们旨在综述调节 p53 表达、功能和稳定性的 circRNA 以及这些分子与 p53 之间可能的相互作用。鉴于 p53 在癌症中的重要性以及 p53 和 circRNA 之间的网络关系，针对这些 circRNA 作为治疗剂的未来临床试验值得关注。
