Liu Siyu, Shi Huifeng, He Shiyu, Hu Lanxin, Zhao Yangyu
Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
National Center for Healthcare Quality Management in Obstetrics, Peking University Third Hospital, Beijing, China.
Int J Gynaecol Obstet. 2025 May;169(2):663-670. doi: 10.1002/ijgo.16097. Epub 2024 Dec 19.
It has been widely reported that there are physiological differences between twin and singleton pregnancies, as evidenced by physiological indicators examined during prenatal period. However, not all physiological indicators have been evaluated. Physiological indicators of twin pregnancies still refer to the standards of single pregnancies and lack precise variation intervals. Therefore, our study compared and analyzed the differences in physiological indicators between twin and singleton pregnancies.
Retrospective cohort data of deliveries at Peking University Third Hospital from January 1, 2012, to February 8, 2021, were utilized. Information of pregnant women, including maternal characteristics, 49 physiological indicators examined during four periods (postpartum, first, second, and third trimester), and pregnancy complications, was extracted from medical records. Mann-Whitney test and multiple linear regressions were conducted to evaluate the differences in physiological indicators between twin and singleton pregnancies and to demonstrate their variation trend throughout gestation.
A total of 40 746 cases were included (38 320 singleton pregnancy cases and 2426 twin pregnancy cases). In twin pregnancies, 16 indicators related to red blood cells, platelets, coagulation function, protein, creatinine, and blood lipids exhibited distinctions compared to singleton pregnancies throughout gestation. The results remained stable regardless of maternal complications.
Twin and singleton pregnancies are in distinct physiological conditions. It is of great necessity to establish specific reference intervals for twin pregnancies. Further study is needed to investigate the impact of physiological indicators on predicting adverse outcomes in twin pregnancies.
已有广泛报道称双胎妊娠与单胎妊娠之间存在生理差异，产前检查的生理指标可证明这一点。然而，并非所有生理指标都得到了评估。双胎妊娠的生理指标仍参照单胎妊娠的标准，缺乏精确的变化区间。因此，我们的研究比较并分析了双胎妊娠与单胎妊娠生理指标的差异。
利用北京大学第三医院2012年1月1日至2021年2月8日分娩的回顾性队列数据。从病历中提取孕妇信息，包括产妇特征、四个时期（产后、孕早期、孕中期和孕晚期）检查的49项生理指标以及妊娠并发症。进行曼-惠特尼检验和多元线性回归，以评估双胎妊娠与单胎妊娠生理指标的差异，并展示其在整个孕期的变化趋势。
共纳入40746例病例（38320例单胎妊娠病例和2426例双胎妊娠病例）。在双胎妊娠中，与红细胞、血小板、凝血功能、蛋白质、肌酐和血脂相关的16项指标在整个孕期与单胎妊娠相比存在差异。无论产妇有无并发症，结果均保持稳定。
双胎妊娠和单胎妊娠处于不同的生理状态。为双胎妊娠建立特定的参考区间非常必要。需要进一步研究来调查生理指标对预测双胎妊娠不良结局的影响。
