Jagu Subhashini, Guidry Auvil Jaime M, Reaman Gregory
Office of Data Sharing, Center for Biomedical Informatics and Information Technology, National Cancer Institute, Rockville.
Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, USA.
Curr Opin Pediatr. 2025 Feb 1;37(1):42-47. doi: 10.1097/MOP.0000000000001422. Epub 2024 Nov 27.
With growing emphasis on data-driven research in pediatric oncology, particularly in the context of advances in molecular characterization and precision medicine, there is an urgent need for comprehensive data-sharing initiatives. This review explores how the Childhood Cancer Data Initiative (CCDI) addresses this critical need.
CCDI plays a key role in enhancing pediatric cancer research by improving data integration, sharing, and collaboration. Its Molecular Characterization Initiative advances the field by leveraging detailed molecular data to inform clinical trials and therapeutic strategies. For small patient populations, such as those with rhabdomyosarcoma, CCDI's efforts in integrating data across institutions are vital for advancing risk-based treatment strategies to achieve meaningful clinical outcomes.
CCDI's advancements in data sharing have profound implications for both clinical practice and research. By enabling precise diagnoses, tailoring treatments based on individual genetic profiles, and addressing the challenges associated with small patient populations, CCDI is driving transformative changes in pediatric oncology. Continued support and expansion of such initiatives are crucial to fully realizing their potential in improving outcomes for children with cancer.
随着儿科肿瘤学中数据驱动研究的重要性日益凸显，尤其是在分子特征分析和精准医学取得进展的背景下，迫切需要全面的数据共享举措。本综述探讨了儿童癌症数据倡议（CCDI）如何满足这一关键需求。
CCDI通过改善数据整合、共享与协作，在加强儿科癌症研究方面发挥着关键作用。其分子特征分析倡议通过利用详细的分子数据为临床试验和治疗策略提供信息，推动了该领域的发展。对于横纹肌肉瘤等小患者群体，CCDI在跨机构整合数据方面的努力对于推进基于风险的治疗策略以实现有意义的临床结果至关重要。
CCDI在数据共享方面的进展对临床实践和研究都具有深远影响。通过实现精确诊断、根据个体基因图谱定制治疗方案以及应对与小患者群体相关的挑战，CCDI正在推动儿科肿瘤学的变革性变化。持续支持和扩展此类举措对于充分发挥其在改善癌症患儿治疗结果方面的潜力至关重要。
