利用大数据进行儿科肿瘤学研究：当前的应用和未来的方向。
Using big data in pediatric oncology: Current applications and future directions.
机构信息
Section of Hematology Oncology, University of Chicago Medicine, Chicago, IL.
Biological Sciences Division, University of Chicago, Chicago, IL.
出版信息
Semin Oncol. 2020 Feb;47(1):56-64. doi: 10.1053/j.seminoncol.2020.02.006. Epub 2020 Feb 29.
Abstract
Pediatric cancer is a rare disease with a low annual incidence, which presents a significant challenge in being able to collect enough data to fuel clinical discoveries. Big data registry trials hold promise to advance the study of pediatric cancers by allowing for the combination of traditional randomized controlled trials with the power of larger cohort sizes. The emergence of big data resources and data-sharing initiatives are becoming transformative for pediatric cancer diagnosis and treatment. This review discusses the uses of big data in pediatric cancer, existing pediatric cancer registry initiatives and research, the challenges in harmonizing these data to improve accessibility for study, and building pediatric data commons and other important future endeavors.
摘要
儿科癌症是一种罕见疾病，年发病率较低，因此很难收集到足够的数据来推动临床发现。大数据注册试验有望通过将传统的随机对照试验与更大的队列规模的优势相结合，来推进儿科癌症的研究。大数据资源和数据共享计划的出现正在改变儿科癌症的诊断和治疗方式。本文讨论了大数据在儿科癌症中的应用、现有的儿科癌症注册计划和研究、协调这些数据以提高研究可及性的挑战，以及建立儿科数据公共设施和其他重要的未来努力。
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