Friedman L S, Dienstag J L, Nelson P W, Russell P S, Cosimi A B
Am J Med. 1985 Feb;78(2):343-5. doi: 10.1016/0002-9343(85)90447-4.
Cyclosporine, a new immunosuppressive agent useful in recipients of a variety of organ transplants, has been associated with a number of adverse effects, most notably nephrotoxicity. This report describes a woman about to undergo liver transplantation in whom intravenous administration of cyclosporine was associated with an apparent anaphylactic reaction resulting in cardiopulmonary arrest. Similar reactions have thus far not been reported after oral administration of cyclosporine. Intravenous cyclosporine must be administered under close supervision and should be avoided in any patients with a history of prior allergic reactions to the drug or to a component of its intravenous formulation.
环孢素是一种新型免疫抑制剂，对多种器官移植受者有用，但它与许多不良反应有关，最显著的是肾毒性。本报告描述了一名即将接受肝移植的女性，静脉注射环孢素后出现明显的过敏反应，导致心肺骤停。迄今为止，口服环孢素后尚未报告过类似反应。静脉注射环孢素必须在密切监督下进行，有该药物或其静脉制剂成分既往过敏反应史的任何患者都应避免使用。
