Howrie D L, Ptachcinski R J, Griffith B P, Hardesty R J, Rosenthal J T, Burckart G J, Venkataramanan R
Drug Intell Clin Pharm. 1985 Jun;19(6):425-7. doi: 10.1177/106002808501900603.
Acute anaphylactoid reactions occurred immediately after initiation of intravenous infusions of cyclosporine in three patients post-organ transplantation. Shortness of breath, flushing, tachypnea, chest pain, pruritus, or urticaria were noted; rapid recovery followed cessation of drug infusion. Subsequently, oral cyclosporine has been used in each patient without recurrence of the observed reaction. The presence of Cremophor EL as an emulsifying agent in the parenteral dosage formulation of cyclosporine is a likely etiology for this acute adverse reaction. Slowed rates of drug infusion and antihistamine premedication may permit continued intravenous cyclosporine use in affected patients.
3例器官移植术后患者在静脉输注环孢素后立即发生急性类过敏反应。出现呼吸急促、面部潮红、呼吸急促、胸痛、瘙痒或荨麻疹；停止药物输注后迅速恢复。随后，每位患者均使用口服环孢素，未再出现上述反应。环孢素注射用剂型中含有聚氧乙烯蓖麻油作为乳化剂，这可能是导致这种急性不良反应的原因。减慢药物输注速度和使用抗组胺药进行预处理可能使受影响患者能够继续静脉使用环孢素。
