给我一个信号（特征）：聚焦于胶质母细胞瘤的癌症干细胞。

Give me a sign(ature): Converging on the CSC of glioblastoma.

作者信息

Patel Kunal S, Dudley Lindsey, Kornblum Harley I

机构信息

Department of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA.

Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA; The Intellectual and Developmental Disabilities Research Center and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

出版信息

Neuron. 2024 Dec 18;112(24):3987-3988. doi: 10.1016/j.neuron.2024.11.012.

DOI:10.1016/j.neuron.2024.11.012

PMID:39701039

Abstract

The identification of stem cells in glioblastomas has been controversial. In this issue of Neuron, Xie et al. establish gene signatures for cellular states and a quiescent cancer stem cell (qCSC) and demonstrate that the qCSC population expands in recurrence.

摘要

胶质母细胞瘤中干细胞的鉴定一直存在争议。在本期《神经元》杂志中，谢等人建立了细胞状态和静止癌症干细胞（qCSC）的基因特征，并证明qCSC群体在复发时会扩大。