Yeh Andrew, Prueitt Robyn L, Kerper Laura E, Beck Barbara D
Gradient, 600 Stewart Street, Suite 1900, Seattle, WA, 98101, USA.
Gradient, One Beacon St., 17th Floor, Boston, MA, 02108, USA.
Regul Toxicol Pharmacol. 2025 Feb;156:105766. doi: 10.1016/j.yrtph.2024.105766. Epub 2024 Dec 17.
To date, only four studies directly measured dermal absorption kinetics of perfluorooctanoic acid (PFOA) in human skin. Reported kinetic parameters spanned two to five orders of magnitude, demonstrating the need to determine the causes of variability and identify the most appropriate dermal absorption factors for use in exposure assessments. We evaluated the reliability and physiological relevance of studies that measured PFOA fractional absorption, steady-state flux (J), and dermal permeability coefficient (K). We verified whether the reported kinetic parameters were measured under appropriate conditions (i.e., fractional absorption under finite dose conditions, and J and K under infinite dose conditions). We recommend the following values measured at the approximate pH of the skin, and in aqueous solvents or relevant consumer product matrices, for use as provisional values in PFOA exposure assessments: 1.6% fractional absorption under finite dose conditions, and 0.132 μg/cm-hr and 0.000044 cm/h for J and K, respectively, under infinite dose conditions. Using the recommended absorption factors, we estimated PFOA exposures in children from soil and water via dermal and ingestion routes. Our results indicate low dermal absorption of PFOA relative to ingestion, and low dermal absorption is expected for per- and polyfluoroalkyl substances (PFAS) with physicochemical properties similar to PFOA.
迄今为止，仅有四项研究直接测量了全氟辛酸（PFOA）在人体皮肤中的真皮吸收动力学。报告的动力学参数跨度为两到五个数量级，这表明有必要确定变异性的原因，并确定用于暴露评估的最合适的真皮吸收因子。我们评估了测量PFOA分数吸收、稳态通量（J）和真皮渗透系数（K）的研究的可靠性和生理相关性。我们验证了报告的动力学参数是否在适当条件下测量（即有限剂量条件下的分数吸收，以及无限剂量条件下的J和K）。我们建议在皮肤近似pH值以及水性溶剂或相关消费品基质中测量的以下值，用作PFOA暴露评估的临时值：有限剂量条件下分数吸收为1.6%，无限剂量条件下J和K分别为0.132μg/cm-hr和0.000044 cm/h。使用推荐的吸收因子，我们估计了儿童通过皮肤和摄入途径从土壤和水中接触PFOA的情况。我们的结果表明，相对于摄入而言，PFOA的皮肤吸收较低，并且预计具有与PFOA相似物理化学性质的全氟和多氟烷基物质（PFAS）的皮肤吸收也较低。
