Decomposing the Brain in Autism: Linking Behavioral Domains to Neuroanatomical Variation and Genomic Underpinnings.

作者信息

Seelemeyer Hanna, Gurr Caroline, Leyhausen Johanna, Berg Lisa M, Pretzsch Charlotte M, Schäfer Tim, Hermila Bassem, Freitag Christine M, Loth Eva, Oakley Bethany, Mason Luke, Buitelaar Jan K, Beckmann Christian F, Floris Dorothea L, Charman Tony, Banaschewski Tobias, Jones Emily, Bourgeron Thomas, Murphy Declan, Ecker Christine

机构信息

Department of Child and Adolescent Psychiatry, University Hospital, Goethe University Frankfurt, Frankfurt am Main, Germany; Brain Imaging Center, Goethe University Frankfurt, Frankfurt am Main, Germany.

出版信息

Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Dec 17. doi: 10.1016/j.bpsc.2024.12.003.

BACKGROUND

Autism is accompanied by highly individualized patterns of neurodevelopmental differences in brain anatomy. This variability makes the neuroanatomy of autism inherently difficult to describe at the group level. Here, we examined interindividual neuroanatomical differences using a dimensional approach that decomposed the domains of social communication and interaction (SCI), restricted and repetitive behaviors (RRBs), and atypical sensory processing (ASP) within a neurodiverse study population. Moreover, we aimed to link the resulting neuroanatomical patterns to specific molecular underpinnings.

METHODS

Neurodevelopmental differences in cortical thickness (CT) and surface area (SA) were correlated with SCI, RRB, and ASP domain scores by regression of a general linear model in a large neurodiverse sample of 288 autistic individuals and 140 nonautistic individuals, ages 6 to 30 years, recruited within the European Autism Interventions Longitudinal European Autism Project (EU-AIMS LEAP). The domain-specific patterns of neuroanatomical variability were subsequently correlated with cortical gene expression profiles via the Allen Human Brain Atlas.

RESULTS

Across groups, behavioral variations in SCI, RRBs, and ASP were associated with interindividual differences in CT and SA in partially non-overlapping frontoparietal, temporal, and occipital networks. These domain-specific imaging patterns were enriched for genes that 1) are differentially expressed in autism, 2) mediate typical brain development, and 3) are associated with specific cortical cell types. Many of these genes were implicated in pathways governing synaptic structure and function.

CONCLUSIONS

Our study corroborates the close relationship between neuroanatomical variation and interindividual differences in autism-related symptoms and traits within the general framework of neurodiversity and links domain-specific patterns of neuroanatomical differences to putative molecular underpinnings.