Ma Ren-Fen, Wu Qian, Pan Yin-Po, Liu Hu, Zhuang Xin-Cheng, Zhang Hua
School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China; School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
Fitoterapia. 2025 Jan;180:106350. doi: 10.1016/j.fitote.2024.106350. Epub 2024 Dec 17.
The Euphorbia plants are famous for their diterpenoid constituents with diverse structures and broad biological activities. Herein, the discovery of 15 ingenane diterpenoids including 10 previously unreported ones (1-10) from Euphorbia antiquorum was presented. Structures of the undescribed compounds were established via detailed spectroscopic analyses. Meanwhile, a preliminary anti-inflammatory screening revealed that compound 6 showed significant inhibitory activity against the production of nitric oxide, as well as downregulated the expression of COX-2 and IL-6, in lipopolysaccharide-stimulated RAW264.7 macrophages. Further mechanistical exploration revealed that compound 6 could exert its anti-inflammatory effect by inhibiting NF-κB and activating Nrf2 signaling pathways.
大戟属植物以其具有多样结构和广泛生物活性的二萜类成分而闻名。在此，报道了从京大戟中发现的15种瑞香烷二萜类化合物，其中包括10种以前未报道的化合物（1-10）。通过详细的光谱分析确定了未描述化合物的结构。同时，初步的抗炎筛选表明，化合物6在脂多糖刺激的RAW264.7巨噬细胞中对一氧化氮的产生具有显著的抑制活性，并下调了COX-2和IL-6的表达。进一步的机制探索表明，化合物6可通过抑制NF-κB和激活Nrf2信号通路发挥其抗炎作用。
