Feng Ling-Fang, Wang Sheng, Zhang Cheng-Cai, Wang Hong-Yang, Guo Xiu-Zhi, Cao Ye, Zhang Yi-Feng, Guo Lan-Ping
State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China Key Laboratory of Biology and Cultivation of Herb Medicine, Ministry of Agriculture and Rural Affairs Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi. 2024 Nov;49(21):5829-5834. doi: 10.19540/j.cnki.cjcmm.20240813.104.
The traditional Chinese medicine Atractlodis Rhizoma is the dried rhizome of the Asteraceae herbal plant Atractylodes lancea, and it has the functions of drying dampness and strengthening the spleen, removing wind and dissipating cold, and brightening the eyes. The sesquiterpenoids in A. lancea are the main ingredients of its pharmacological activities in clinical practice, including atractylone, β-eudesmol, and hinesol, which possess anti-inflammation, antibacterial, antiviral, and hepatoprotective effects. This study focused on the biosynthesis of sesquiterpenoids in A. lancea, summarized the proportion of the main active ingredients in A. lancea from the genuine region and the non-genuine region, elaborated on the research progress of genes related to biosynthesis pathways, and systematically sorted out the biotic and abiotic factors affecting their biosynthesis, so as to provide a theoretical basis for further research on the biosynthetic mechanism of sesquiterpenoids in A. lancea and development of high-quality medicinal materials of A. lancea.
中药苍术为菊科草本植物茅苍术的干燥根茎，具有燥湿健脾、祛风散寒、明目等功效。茅苍术中的倍半萜类化合物是其临床药理活性的主要成分，包括苍术酮、β-桉叶醇和汉黄芩素，具有抗炎、抗菌、抗病毒和保肝作用。本研究聚焦于茅苍术中倍半萜类化合物的生物合成，总结了道地产区和非道地产区茅苍术主要活性成分的比例，阐述了生物合成途径相关基因的研究进展，并系统梳理了影响其生物合成的生物和非生物因素，以期为进一步研究茅苍术中倍半萜类化合物的生物合成机制及开发茅苍术优质药材提供理论依据。
