Lin M T, Tsay B L
Am J Physiol. 1985 Jan;248(1 Pt 2):R108-12. doi: 10.1152/ajpregu.1985.248.1.R108.
Seventy-nine units in the striatal region were examined in 48 urethan-anesthetized rats. When these units were classified by their thermal responsiveness, proportions of the cold-responsive, warm-responsive, and thermally unresponsive units were 25.4, 35.4, and 39.2%, respectively, of the total units tested. Either microiontophoretically or systemically administered apomorphine (a dopamine agonist) and haloperidol (a dopamine antagonist) affected (inhibited and/or excited) most (86.5-100%) cold-responsive units. In contrast, only a small percentage of the warm-responsive (28.6-43.8%) or thermally unresponsive (0-19.2%) units were affected by both apomorphine and and haloperidol. Furthermore it was found that most (73-100%) cold-responsive units were inhibited by apomorphine but excited by haloperidol; the inhibitory responses of the unit activity induced by apomorphine were antagonized by haloperidol. The reciprocal relationships between apomorphine and haloperidol were not observed in most warm-responsive (76.2-85.7%) or thermally unresponsive (80.8-100%) units. The data demonstrate that many striatal neurons are influenced by thermal afferent activation in the scrotum. The results also provide a neuronal basis for the hypothesis that the dopaminergic receptors located in the cold-responsive neurons of the striatum have effects on metabolic heat production in rats.
在48只经乌拉坦麻醉的大鼠中，对纹状体区域的79个单位进行了检查。当根据这些单位的热反应性进行分类时，冷反应性、热反应性和无热反应性单位在测试的总单位中所占比例分别为25.4%、35.4%和39.2%。无论是通过微量离子电泳法还是全身给药，阿扑吗啡（一种多巴胺激动剂）和氟哌啶醇（一种多巴胺拮抗剂）都会影响（抑制和/或兴奋）大多数（86.5 - 100%）冷反应性单位。相比之下，只有一小部分热反应性（28.6 - 43.8%）或无热反应性（0 - 19.2%）单位受到阿扑吗啡和氟哌啶醇的影响。此外，还发现大多数（73 - 100%）冷反应性单位被阿扑吗啡抑制但被氟哌啶醇兴奋；阿扑吗啡诱导的单位活动的抑制反应被氟哌啶醇拮抗。在大多数热反应性（76.2 - 85.7%）或无热反应性（80.8 - 100%）单位中未观察到阿扑吗啡和氟哌啶醇之间的这种相互关系。数据表明，许多纹状体神经元受到阴囊内热传入激活的影响。这些结果还为以下假设提供了神经元基础，即位于纹状体冷反应性神经元中的多巴胺能受体对大鼠的代谢产热有影响。
