Lin M T, Uang W N, Chan H K
Neuropharmacology. 1984 May;23(5):591-4. doi: 10.1016/0028-3908(84)90035-2.
Effects of thermal stimulation of the scrotum and of iontophoretic application of morphine on the activity of neurones in the preoptic anterior hypothalamic area were observed in 30 urethane-anaesthetised rats. The proportions of cold-responsive, warm-responsive and thermally unresponsive units were 20.7, 28.3 and 51%, respectively, of the total number of neurones tested. Iontophoretic application of morphine to neurones in the preoptic anterior hypothalamic area in rats resulted in excitation of the majority of cold-responsive cells and inhibition of the majority of warm-responsive cells tested. However, most of the thermally unresponsive cells were unaffected by application of morphine. These results provide a neuronal basis for the hypothesis that morphine, when administered directly into the hypothalamus, facilitates heat production and inhibits heat loss, which leads to hyperthermia.
在30只经乌拉坦麻醉的大鼠中，观察了阴囊热刺激和吗啡离子导入对视前区下丘脑前部神经元活动的影响。冷反应性、温反应性和热无反应性单位的比例分别占所测试神经元总数的20.7%、28.3%和51%。对大鼠视前区下丘脑前部的神经元进行吗啡离子导入，导致所测试的大多数冷反应性细胞兴奋，大多数温反应性细胞受到抑制。然而，大多数热无反应性细胞不受吗啡应用的影响。这些结果为以下假设提供了神经元基础：吗啡直接注入下丘脑时，会促进产热并抑制散热，从而导致体温过高。
