Kang Junlin, Tian Shilai, Zhang Lei, Yang Gang
The First Hospital of Lanzhou University, Lanzhou City, Gansu Province, China.
Gansu Provincial Hospital, Lanzhou City, Gansu Province, China.
Chin Neurosurg J. 2024 Feb 13;10(1):6. doi: 10.1186/s41016-024-00357-4.
Spontaneous subarachnoid hemorrhage (SAH), mainly caused by ruptured intracranial aneurysms, is a serious acute cerebrovascular disease. Early brain injury (EBI) is all brain injury occurring within 72 h after SAH, mainly including increased intracranial pressure, decreased cerebral blood flow, disruption of the blood-brain barrier, brain edema, oxidative stress, and neuroinflammation. It activates cell death pathways, leading to neuronal and glial cell death, and is significantly associated with poor prognosis. Ferroptosis is characterized by iron-dependent accumulation of lipid peroxides and is involved in the process of neuron and glial cell death in early brain injury. This paper reviews the research progress of ferroptosis in early brain injury after subarachnoid hemorrhage and provides new ideas for future research.
自发性蛛网膜下腔出血（SAH）主要由颅内动脉瘤破裂引起，是一种严重的急性脑血管疾病。早期脑损伤（EBI）是指SAH后72小时内发生的所有脑损伤，主要包括颅内压升高、脑血流量减少、血脑屏障破坏、脑水肿、氧化应激和神经炎症。它激活细胞死亡途径，导致神经元和胶质细胞死亡，并与预后不良显著相关。铁死亡的特征是脂质过氧化物的铁依赖性积累，并参与早期脑损伤中神经元和胶质细胞死亡的过程。本文综述了蛛网膜下腔出血后早期脑损伤中铁死亡的研究进展，为未来的研究提供了新思路。
