Godinho Diogo P, Yanez Romana J R, Duque Paula
GIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
GIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
Trends Plant Sci. 2025 Jun;30(6):615-628. doi: 10.1016/j.tplants.2024.11.010. Epub 2024 Dec 18.
Plant immunity involves a complex and finely tuned response to a wide variety of pathogens. Alternative splicing, a post-transcriptional mechanism that generates multiple transcripts from a single gene, enhances both the versatility and effectiveness of the plant immune system. Pathogen infection induces alternative splicing in numerous plant genes involved in the two primary layers of pathogen recognition: pattern-triggered immunity (PTI) and effector-triggered immunity (ETI). However, the mechanisms underlying pathogen-responsive alternative splicing are just beginning to be understood. In this article, we review recent findings demonstrating that the interaction between pathogen elicitors and plant receptors modulates the phosphorylation status of splicing factors, altering their function, and that pathogen effectors target components of the host spliceosome, controlling the splicing of plant immunity-related genes.
植物免疫涉及对多种病原体的复杂且精细调节的反应。可变剪接是一种转录后机制，可从单个基因产生多个转录本，它增强了植物免疫系统的通用性和有效性。病原体感染会在参与病原体识别两个主要层面的众多植物基因中诱导可变剪接，这两个层面分别是模式触发免疫（PTI）和效应子触发免疫（ETI）。然而，病原体响应性可变剪接的潜在机制才刚刚开始被理解。在本文中，我们综述了近期的研究结果，这些结果表明病原体激发子与植物受体之间的相互作用调节了剪接因子的磷酸化状态，改变了它们的功能，并且病原体效应子靶向宿主剪接体的组分，从而控制植物免疫相关基因的剪接。
