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新生儿肥胖的共同代谢和应激途径。

Shared metabolic and stress pathways to neonatal adiposity.

作者信息

Entringer Sonja, Desoye Gernot

机构信息

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Medical Psychology, 10117 Berlin, Germany; Department of Pediatrics, School of Medicine, University of California, Irvine, CA, USA; German Center for Mental Health, Charitéplatz 1, 10117, Berlin, Germany.

Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria.

出版信息

Trends Endocrinol Metab. 2025 May;36(5):392-394. doi: 10.1016/j.tem.2024.11.012. Epub 2024 Dec 18.

DOI:10.1016/j.tem.2024.11.012
PMID:39701916
Abstract

Perceived stress levels, prevalence of pregnancies complicated by metabolic disorders, and childhood obesity have been increasing steadily. We here propose a pathway integrating stress-responsive biological systems into the established effects of maternal diabetes and obesity during pregnancy, overall exerting a combined contribution to offspring adiposity risk.

摘要

感知到的压力水平、并发代谢紊乱的妊娠患病率以及儿童肥胖率一直在稳步上升。我们在此提出一条途径,将应激反应生物系统整合到孕期母亲糖尿病和肥胖的既定影响中,总体上对后代肥胖风险产生综合影响。

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