人体假饲时胃内氢离子和碳酸氢根离子的分泌情况。

Gastric H+ and HCO3- secretion in response to sham feeding in humans.

作者信息

Feldman M

出版信息

Am J Physiol. 1985 Feb;248(2 Pt 1):G188-91. doi: 10.1152/ajpgi.1985.248.2.G188.

DOI:10.1152/ajpgi.1985.248.2.G188

Abstract

Sham feeding (SF) was used to evaluate the effect of physiological vagal stimulation on gastric acid (H+) and bicarbonate (HCO3-) secretion in humans, as well as on parietal and nonparietal volume secretion. A recently validated method, derived from a two-component model of gastric secretion, was employed. SF increased both H+ secretion from parietal cells (P less than 0.001) and HCO3- secretion from nonparietal cells (P less than 0.01), although the H+ response was greater and more prolonged. Atropine significantly inhibited not only H+ secretion but also HCO3- and nonparietal volume secretion. Peak H+ secretion during SF averaged approximately 27 mmol/h, whereas peak HCO3- secretion averaged approximately 6 mmol/h. When H+ secretion was already maximally stimulated by an intravenous pentagastrin infusion, SF actually reduced gastric juice acidity and osmolality due to neutralization of H+ by HCO3- and to dilution of H+ by nonparietal secretions. These studies therefore indicate that vagal stimulation induced by SF increases both H+ and HCO3- secretion in humans and that this process is cholinergically dependent.

摘要

假饲（SF）用于评估生理性迷走神经刺激对人体胃酸（H⁺）和碳酸氢盐（HCO₃⁻）分泌以及壁细胞和非壁细胞容量分泌的影响。采用了一种最近从胃分泌的双组分模型推导出来并经过验证的方法。假饲增加了壁细胞的H⁺分泌（P<0.001）和非壁细胞的HCO₃⁻分泌（P<0.01），尽管H⁺反应更大且更持久。阿托品不仅显著抑制H⁺分泌，还抑制HCO₃⁻和非壁细胞容量分泌。假饲期间的H⁺分泌峰值平均约为27 mmol/h，而HCO₃⁻分泌峰值平均约为6 mmol/h。当通过静脉注射五肽胃泌素使H⁺分泌受到最大刺激时，由于HCO₃⁻对H⁺的中和作用以及非壁细胞分泌物对H⁺的稀释作用，假饲实际上降低了胃液的酸度和渗透压。因此，这些研究表明，假饲诱导的迷走神经刺激增加了人体的H⁺和HCO₃⁻分泌，并且这个过程是胆碱能依赖性的。