Pedersen Jakob Bjørbaek, Martensen Anna, Funder Pia, Bakke Skule Arnesen, Bhavsar Rajesh Prabhakar, Strøm Thomas
Department of Anesthesia and Critical Care Medicine, Hospital Sønderjylland, University Hospital of Southern Denmark, Aabenraa, Denmark.
Department of Anesthesia and Critical Care Medicine, Lille Baelt Hospital, Kolding, Denmark.
BMC Anesthesiol. 2024 Dec 19;24(1):466. doi: 10.1186/s12871-024-02858-2.
Venous cannulation is widely used in healthcare systems, and for many patients, it is painful and distressing. We hypothesized that the rapid onset of cryospray use would reduce pain from venous cannulation compared to the use of a placebo spray.
The trial was a prospective randomized placebo-controlled trial including 130 adult patients scheduled for elective surgery. Patients were randomized to receive either cryospray or placebo before venous cannulation. The primary outcome was patient-reported pain from vein puncture.
There were no differences in the baseline variables between the two groups with respect to age, sex, height, weight or ASA class. Patients in the cryospray group indicated more pain or discomfort with the application of the spray (0 (0-2.5)) than with the application of the placebo spray (0 (0-0)) (P < 0.005), as measured by the Numeric Rating Scale (NRS). Patients in the placebo group reported more pain with vein puncture than did those in the cryospray group (1 (0-3) vs. 3 [2-5], P < 0.005). When asked if the patient would have the same spray in case of canulation again, 57 patients from the cryospray group reported yes compared to 34 patients in the control group (P < 0.005).
This randomized study found that cryospray significantly reduced pain during venous cannulation without increasing procedure difficulty. Patients reported lower pain scores and a greater preference for cryospray in future procedures, supporting its use as an effective pain relief method in elective surgery.
ClinicalTrials. gov Identifier: NCT04865783 (28-04-2021).
静脉置管在医疗系统中广泛应用，对许多患者来说，这一过程会带来疼痛和痛苦。我们推测，与使用安慰剂喷雾相比，快速起效的冷冻喷雾可减轻静脉置管引起的疼痛。
该试验为前瞻性随机安慰剂对照试验，纳入130例计划接受择期手术的成年患者。患者在静脉置管前被随机分组，分别接受冷冻喷雾或安慰剂。主要结局是患者报告的静脉穿刺疼痛。
两组在年龄、性别、身高、体重或美国麻醉医师协会（ASA）分级等基线变量方面无差异。根据数字评分量表（NRS）测量，冷冻喷雾组患者表示使用喷雾时（0[0 - 2.5]）比使用安慰剂喷雾时（0[0 - 0]）疼痛或不适更明显（P < 0.005）。安慰剂组患者报告的静脉穿刺疼痛程度高于冷冻喷雾组（1[0 - 3]对3[2 - 5]，P < 0.005）。当被问及如果再次进行置管患者是否会选择相同的喷雾时，冷冻喷雾组有57例患者回答是，而对照组为34例患者（P < 0.005）。
这项随机研究发现，冷冻喷雾可显著减轻静脉置管期间的疼痛，且不增加操作难度。患者报告疼痛评分较低，并且在未来操作中更倾向于使用冷冻喷雾，这支持了其作为择期手术中一种有效的疼痛缓解方法的应用。
ClinicalTrials.gov标识符：NCT04865783（2021年4月28日）。
