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使用马H3N8血凝素作为一种具有广泛保护作用的流感疫苗免疫原。

Use of equine H3N8 hemagglutinin as a broadly protective influenza vaccine immunogen.

作者信息

Verhoeven David, Sponseller Brett A, Crowe James E, Bangaru Sandhya, Webby Richard J, Lee Brian M

机构信息

Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, USA.

Department of Veterinary Clinical Service, Iowa State University, Ames, IA, USA.

出版信息

NPJ Vaccines. 2024 Dec 19;9(1):247. doi: 10.1038/s41541-024-01037-1.

DOI:10.1038/s41541-024-01037-1
PMID:39702334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11659547/
Abstract

Development of an efficacious universal influenza vaccines remains a long-sought goal. Current vaccines have shortfalls such as mid/low efficacy and needing yearly strain revisions to account for viral drift/shift. Horses undergo bi-annual vaccines for the H3N8 equine influenza virus, and surveillance of sera from vaccinees demonstrated very broad reactivity and neutralization to many influenza strains. Subsequently, vaccinating mice using the equine A/Kentucky/1/1991 strain or recombinant hemagglutinin (HA) induced similar broadly reactive and neutralizing antibodies to seasonal and high pathogenicity avian influenza strains. Challenge of vaccinated mice protected from lethal virus challenges across H1N1 and H3N2 strains. This protection correlated with neutralizing antibodies to the HA head, esterase, and stem regions. Vaccinated ferrets were also protected after challenge with H1N1 influenza A/07/2009 virus using whole viral or HA. These data suggest that equine H3N8 induces broad protection against multiple influenzas using a unique antigen that diverges from other universal vaccine approaches.

摘要

开发一种有效的通用流感疫苗仍然是一个长期追求的目标。目前的疫苗存在诸如中/低效力以及需要每年修订毒株以应对病毒漂移/转变等不足之处。马匹每半年接种一次针对H3N8马流感病毒的疫苗，对疫苗接种者血清的监测显示出对许多流感毒株具有非常广泛的反应性和中和作用。随后，使用马源A/肯塔基/1/1991毒株或重组血凝素（HA）对小鼠进行接种，诱导出了对季节性和高致病性禽流感毒株具有类似广泛反应性和中和作用的抗体。对接种疫苗的小鼠进行攻毒试验，可使其免受H1N1和H3N2毒株致死性病毒攻击。这种保护作用与针对HA头部、酯酶和茎区的中和抗体相关。使用全病毒或HA对接种疫苗的雪貂用H1N1甲型流感/07/2009病毒进行攻毒后，它们也受到了保护。这些数据表明，马源H3N8利用一种与其他通用疫苗方法不同的独特抗原，对多种流感病毒诱导出广泛的保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2ae/11659547/27a518492232/41541_2024_1037_Fig7_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2ae/11659547/27a518492232/41541_2024_1037_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2ae/11659547/49178f69300b/41541_2024_1037_Fig1_HTML.jpg
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