用于评估心血管风险的细胞外囊泡分析中的年龄和性别相关差异：EVaging指数

Age- and sex-related variations in extracellular vesicle profiling for the assessment of cardiovascular risk: the EVaging index.

作者信息

Burrello Jacopo, Goi Jessica, Burrello Alessio, Vacchi Elena, Rendon-Angel Azucena, Lazzarini Edoardo, Bianco Giovanni, Limongelli Vittorio, Vassalli Giuseppe, Cereda Carlo W, Monticone Silvia, Mulatero Paolo, Bussolati Benedetta, Alimonti Andrea, Camici Giovanni G, Melli Giorgia, Osto Elena, Pedrazzini Giovanni, Lucio Barile

机构信息

Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.

Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Torino, Torino, Italy.

出版信息

NPJ Aging. 2024 Dec 19;10(1):63. doi: 10.1038/s41514-024-00189-7.

DOI:10.1038/s41514-024-00189-7

PMID:39702460

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11659617/

Abstract

Extracellular vesicles (EVs) offer valuable diagnostic and prognostic insights for cardiovascular (CV) diseases, but the influence of age-related chronic inflammation ("inflammaging") and sex differences on EV profiles linked to CV risk remains unclear. This study aimed to use EV profiling to predict age and stratify patients by CV risk. We developed an EVaging index by analyzing surface antigen profiles of serum EVs from 625 participants, aged 20 to 94 years, across varying CV risk groups. The EVaging index was associated with age in healthy individuals and distinguished CV risk profiles in patients, correlating with CV outcomes and likelihood of fatal CV events according to the European Society of Cardiology (ESC) SCORE, and reflecting age-associated comorbidities. While changes in disease-related EV fingerprint adds complexity in CV patients, EV profiling may help assess biological aging and CV risk, emphasizing EVs' roles in inflammaging.

摘要

细胞外囊泡（EVs）为心血管（CV）疾病提供了有价值的诊断和预后见解，但与年龄相关的慢性炎症（“炎症衰老”）和性别差异对与CV风险相关的EV谱的影响仍不清楚。本研究旨在利用EV谱来预测年龄并按CV风险对患者进行分层。我们通过分析来自625名年龄在20至94岁之间、处于不同CV风险组的参与者血清EVs的表面抗原谱，开发了一个EV衰老指数。EV衰老指数与健康个体的年龄相关，并区分了患者的CV风险谱，根据欧洲心脏病学会（ESC）SCORE与CV结局和致命CV事件的可能性相关，且反映了与年龄相关的合并症。虽然疾病相关的EV指纹变化增加了CV患者的复杂性，但EV谱分析可能有助于评估生物衰老和CV风险，强调了EVs在炎症衰老中的作用。