未服用药物及接受锂盐治疗的躁狂症患者红细胞的生化异常

Biochemical RBC abnormalities in drug-free and lithium-treated manic patients.

作者信息

Jope R S, Tolbert L C, Wright S M, Walter-Ryan W

出版信息

Am J Psychiatry. 1985 Mar;142(3):356-8. doi: 10.1176/ajp.142.3.356.

DOI:10.1176/ajp.142.3.356

Abstract

RBCs from two lithium-free manic patients displayed lower choline transport and higher choline concentrations and methionine S-adenosyltransferase activity than those of controls. Lithium therapy decreased RBC methionine S-adenosyltransferase activity to normal, decreased choline transport further, and increased choline concentrations further.

摘要

两名无锂躁狂症患者的红细胞显示出比对照组更低的胆碱转运、更高的胆碱浓度和蛋氨酸S-腺苷转移酶活性。锂治疗使红细胞蛋氨酸S-腺苷转移酶活性降至正常，进一步降低胆碱转运，并进一步提高胆碱浓度。