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PAX5::AUTS2儿童B细胞急性淋巴细胞白血病:一种易复发的遗传亚型,常累及中枢神经系统且预后不良。

PAX5::AUTS2 childhood B-ALL: a relapse-prone genetic subtype with frequent central nervous system involvement and a poor outcome.

作者信息

Caye-Eude Aurélie, Fazio Grazia, Pastorczak Agata, Boer Judith M, Steinemann Doris, Ganguli Debdutta, Sonneveld Edwin, Haslinger Sabrina, D'Andrea Lucía, Bradtke Jutta, Lopes Bruno A, Zaliova Marketa, Escherich Gabriele, König Margit, Fortschegger Klaus, Inthal Andrea, Stasevich Irina, Emerenciano Mariana, Trka Jan, Castillo Luis, Parihar Mayur, Moorman Anthony V, Bergmann Anke K, den Boer Monique L, Młynarski Wojciech, Cazzaniga Giovanni, Cavé Hélène, Nebral Karin, Schinnerl Dagmar, Strehl Sabine

机构信息

Department of Genetics, University Hospital Robert Debré, Paris, France.

INSERM UMR_S1131, Institut de Recherche Saint-Louis, Université Paris-Cité, Paris, France.

出版信息

Leukemia. 2025 Feb;39(2):482-486. doi: 10.1038/s41375-024-02502-5. Epub 2024 Dec 19.

DOI:10.1038/s41375-024-02502-5
PMID:39702796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11794147/
Abstract

[Image: see text]

摘要

[图像:见正文]

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f62/11794147/edf543fbcc54/41375_2024_2502_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f62/11794147/edf543fbcc54/41375_2024_2502_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f62/11794147/edf543fbcc54/41375_2024_2502_Fig1_HTML.jpg

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Deciphering the molecular complexity of the IKZF1 genomic profile using Optical Genome Mapping.利用光学基因组图谱解析IKZF1基因组图谱的分子复杂性。
Haematologica. 2024 May 1;109(5):1582-1587. doi: 10.3324/haematol.2023.284115.
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Blinatumomab Added to Chemotherapy in Infant Lymphoblastic Leukemia.Blinatumomab 联合化疗治疗婴儿急性淋巴细胞白血病。
N Engl J Med. 2023 Apr 27;388(17):1572-1581. doi: 10.1056/NEJMoa2214171.
4
Genetic characteristics and treatment outcome in infants with KMT2A germline B-cell precursor acute lymphoblastic leukemia: Results of MLL-Baby protocol.KMT2A种系B细胞前体急性淋巴细胞白血病婴儿的遗传特征与治疗结果:MLL-Baby方案的结果
Pediatr Blood Cancer. 2023 Apr;70(4):e30204. doi: 10.1002/pbc.30204. Epub 2023 Jan 30.
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Integrative genomic analysis of childhood acute lymphoblastic leukaemia lacking a genetic biomarker in the UKALL2003 clinical trial.英国 ALL2003 临床试验中缺乏遗传生物标志物的儿童急性淋巴细胞白血病的综合基因组分析。
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