Harper J S, London W T, Sever J L
Am J Trop Med Hyg. 1985 Jan;34(1):50-7. doi: 10.4269/ajtmh.1985.34.50.
Five drug regimens for the treatment of acute toxoplasmosis were compared in a monkey model. Systemic disease that is almost always fatal in squirrel monkeys within 7-9 days was produced by oral inoculation of a brain suspension made from mice chronically infected with the Beverly strain of Toxoplasma gondii. All untreated controls died of toxoplasmosis (6/6) while treatment gave the following results: sulfamethoxazole, 0/3; spiramycin, 5/5; clindamycin/sulfadiazine (CLD/SLD), 0/4; pyrimethamine/sulfadiazine (PYR/SLD), 0/5; trimethoprim/sulfamethoxazole (TMP/SMZ), 0/4. Three of the five monkeys treated with CLD/SLD died during or shortly after the experiment from probable CLD toxicity. Sulfonamides alone or in combination with PYR or TMP were significantly more effective than spiramycin in treating toxoplasmosis in this model. The dose regimen used in this study did not allow us to determine if the addition of PYR or TMP changed the protection of sulfa alone.
在一个猴子模型中比较了五种治疗急性弓形虫病的药物方案。通过口服接种由慢性感染刚地弓形虫贝弗利株的小鼠制成的脑悬液，在松鼠猴中引发了几乎总是在7 - 9天内致命的全身性疾病。所有未治疗的对照均死于弓形虫病（6/6），而治疗结果如下：磺胺甲恶唑，0/3；螺旋霉素，5/5；克林霉素/磺胺嘧啶（CLD/SLD），0/4；乙胺嘧啶/磺胺嘧啶（PYR/SLD），0/5；甲氧苄啶/磺胺甲恶唑（TMP/SMZ），0/4。接受CLD/SLD治疗的五只猴子中有三只在实验期间或实验后不久死于可能的CLD毒性。在该模型中，单独使用磺胺类药物或与PYR或TMP联合使用在治疗弓形虫病方面比螺旋霉素显著更有效。本研究中使用的给药方案不允许我们确定添加PYR或TMP是否改变了单独使用磺胺类药物的保护效果。
