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表现为胸膜增厚和胸腔积液的浆母细胞淋巴瘤：一例报告

Plasmablastic Lymphoma Manifesting As Pleural Thickening and Effusion: A Case Report.

作者信息

Elsayed Mohammed, Ali Abdelrahman, Andrijevskiene Giedre

机构信息

Medicine, The James Cook University Hospital, Middlesbrough, GBR.

Medicine and Surgery, The James Cook University Hospital, Middlesbrough, GBR.

出版信息

Cureus. 2024 Nov 18;16(11):e73961. doi: 10.7759/cureus.73961. eCollection 2024 Nov.

DOI:10.7759/cureus.73961
PMID:39703249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11656034/
Abstract

Plasmablastic lymphoma (PbL) is a subtype of diffuse large B-cell lymphoma, primarily linked to human immunodeficiency virus (HIV) infection. This case report presents a 34-year-old HIV-positive patient who exhibited unusual signs of pleural thickening and effusion. Initial evaluations, including imaging and pleural fluid analysis, suggested thoracic empyema. However, histopathological examination ultimately revealed a diagnosis of PbL. Cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) chemotherapy were initiated, but the patient passed away within a few months. This case highlights the complexity of diagnosing PBL and its poor prognosis, particularly in immunocompromised individuals, stressing the importance of early detection and intervention.

摘要

浆母细胞淋巴瘤（PbL）是弥漫性大B细胞淋巴瘤的一种亚型，主要与人类免疫缺陷病毒（HIV）感染有关。本病例报告介绍了一名34岁的HIV阳性患者，该患者表现出胸膜增厚和胸腔积液的异常体征。包括影像学和胸腔积液分析在内的初步评估提示为胸腔积脓。然而，组织病理学检查最终确诊为PbL。开始使用环磷酰胺、阿霉素、长春新碱和泼尼松龙（CHOP）进行化疗，但患者在几个月内去世。本病例突出了诊断PbL的复杂性及其预后不良，尤其是在免疫功能低下的个体中，强调了早期检测和干预的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deb5/11656034/503776239730/cureus-0016-00000073961-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deb5/11656034/45ce996b1188/cureus-0016-00000073961-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deb5/11656034/42e995e04a6a/cureus-0016-00000073961-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deb5/11656034/289a97914717/cureus-0016-00000073961-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deb5/11656034/819cb3bba215/cureus-0016-00000073961-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deb5/11656034/4810e23ea883/cureus-0016-00000073961-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deb5/11656034/493a43f15e26/cureus-0016-00000073961-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deb5/11656034/503776239730/cureus-0016-00000073961-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deb5/11656034/45ce996b1188/cureus-0016-00000073961-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deb5/11656034/42e995e04a6a/cureus-0016-00000073961-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deb5/11656034/289a97914717/cureus-0016-00000073961-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deb5/11656034/819cb3bba215/cureus-0016-00000073961-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deb5/11656034/4810e23ea883/cureus-0016-00000073961-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deb5/11656034/493a43f15e26/cureus-0016-00000073961-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deb5/11656034/503776239730/cureus-0016-00000073961-i08.jpg

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