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感染性原发性骨套细胞淋巴瘤伴多椎体受累

Infected Primary Bone Mantle Cell Lymphoma with Multiple Vertebral Involvement.

作者信息

Bougossa Rebeh, Larbi Fatma, Mabrouk Asma Ben, Jomaa Olfa, Chelli Jihene

机构信息

Department of Endocrinology and Internal Medicine, Tahar Sfar University Hospital, Mahdia, Tunisia.

Department of Rheumatology, Tahar Sfar University Hospital, Mahdia, Tunisia.

出版信息

Int J Hematol Oncol Stem Cell Res. 2024 Oct 1;18(4):403-406. doi: 10.18502/ijhoscr.v18i4.16765.

Abstract

Primary vertebral lymphoma is an exceedingly rare entity. We hereby report a case of a 67-year-old male who presented to our department with fever, weight loss, and progressively worsening lower back pain radiating to the right hip. Physical examination showed pain on percussion of the dorsal and lumbar spine and tenderness on palpation of the right upper thigh area. The radiographic findings revealed numerous vertebral lesions with a right psoas abscess extending to the right upper thigh. Intravenous antibiotic therapy was initiated and the patient underwent an incision and drainage of the psoas abscess with a favourable outcome. However, given the suspicious imaging findings of the osseous lesions suggestive of malignancy, a vertebral biopsy was performed and yielded histo-pathological findings consistent with bone mantle cell lymphoma. To the best of our knowledge, this is the first case of an infected primary bone mantle cell lymphoma with multiple vertebral involvement. The diagnosis is challenging and can be confused with other diseases.

摘要

原发性脊柱淋巴瘤是一种极为罕见的疾病。我们在此报告一例67岁男性患者,他因发热、体重减轻以及逐渐加重的下背部疼痛并向右臀部放射而前来我院就诊。体格检查发现胸腰椎叩击痛以及右大腿上部触压痛。影像学检查结果显示有多处椎体病变,伴有一个向右大腿上部延伸的右腰大肌脓肿。开始进行静脉抗生素治疗,患者接受了腰大肌脓肿切开引流术,结果良好。然而,鉴于骨病变的可疑影像学表现提示恶性肿瘤,遂进行了椎体活检,组织病理学结果与骨套细胞淋巴瘤一致。据我们所知,这是首例伴有多个椎体受累的感染性原发性骨套细胞淋巴瘤病例。该诊断具有挑战性,可能会与其他疾病相混淆。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffed/11652700/5c509f1a8e00/IJHOSCR-18-403-g001.jpg

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