原发性骨淋巴瘤：病例系列及文献综述
Primary Bone Lymphoma: A Case Series and Review of Literature.
作者信息
Bindal Poorva, Desai Aakash, Delasos Lukas, Mulay Sudhanshu, Vredenburgh James
机构信息
Department of Hematology and Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Department of Internal Medicine, University of Connecticut Health Center, Farmington, CT, USA.
出版信息
Case Rep Hematol. 2020 Apr 10;2020:4254803. doi: 10.1155/2020/4254803. eCollection 2020.
Primary bone lymphoma (PBL) is a subtype of lymphoma that exclusively affects skeletal tissue. Despite the relatively common involvement of skeletal structures as a manifestation of non-Hodgkin's lymphoma (NHL), primary and exclusive involvement of the skeletal system is rare. The prevalence of PBL is estimated to be 3-7% amongst primary bone tumors and less than 2% amongst all lymphomas in adults. However, the definition of primary bone lymphoma has been inconsistent over time. Within our institution, we identified four cases of primary bone lymphoma based on diagnostic criteria formed from the general consensus of multiple organizations, including the World Health Organization (WHO) and International Extranodal Lymphoma Study Group (IELSG). Here, we discuss the distinct characteristics amongst these cases in addition to performing a systematic review of current literature regarding this lymphoproliferative entity.
原发性骨淋巴瘤（PBL）是淋巴瘤的一种亚型，仅累及骨骼组织。尽管骨骼结构作为非霍奇金淋巴瘤（NHL）的一种表现相对常见，但骨骼系统的原发性和排他性受累却很罕见。据估计，原发性骨淋巴瘤在原发性骨肿瘤中的患病率为3%-7%，在所有成人淋巴瘤中的患病率不到2%。然而，原发性骨淋巴瘤的定义一直以来并不一致。在我们机构，我们根据包括世界卫生组织（WHO）和国际结外淋巴瘤研究组（IELSG）在内的多个组织的普遍共识形成的诊断标准，确定了4例原发性骨淋巴瘤病例。在此，我们除了对有关这种淋巴增殖性疾病的当前文献进行系统综述外，还讨论了这些病例中的独特特征。
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