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缓解期华氏巨球蛋白血症患者中嗜酸性胃肠道疾病的序贯发生：一份附有文献综述的罕见报告

Sequential Occurrence of Eosinophilic Gastrointestinal Disease in a Case of Waldenström's Macroglobulinemia in Remission: An Unusual Report with Review.

作者信息

Jitani Ankit, Mundhe Mayur Babasaheb, Husain Kazi Wajid, Menghani Hemant, Desai Maharshi, Nair Velu

机构信息

Apollo CBCC Cancer Care, Ahmedabad, Gujarat, India.

Apollo Hospitals International Ltd, Ahmedabad, Gujarat, India.

出版信息

Int J Hematol Oncol Stem Cell Res. 2024 Oct 1;18(4):411-414. doi: 10.18502/ijhoscr.v18i4.16767.

DOI:10.18502/ijhoscr.v18i4.16767
PMID:39703472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11652698/
Abstract

Waldenström macroglobulinemia (WM) is a rare lymphoproliferative malignancy presenting with para-proteinemia. The symptoms are attributable to both lymphoproliferation and IgM flare. Gastrointestinal manifestations are not uncommon. It is an indolent disease with good response to chemoimmunotherapy but with possible persistence of asymptomatic paraproteinemia. Resurgence of gastrointestinal symptoms in a patient of WM maintaining reasonable response warrant a thorough search for alternate pathology. Herein we describe a rare case of sequential occurrence of WM with Eosinophilic Gastrointestinal Disease posing a diagnostic and therapeutic challenge.

摘要

华氏巨球蛋白血症（WM）是一种罕见的伴有副蛋白血症的淋巴增殖性恶性肿瘤。其症状归因于淋巴增殖和IgM激增。胃肠道表现并不少见。它是一种惰性疾病，对化疗免疫疗法反应良好，但可能存在无症状副蛋白血症。在对化疗免疫疗法保持合理反应的WM患者中，胃肠道症状复发需要彻底排查其他病理情况。在此，我们描述了一例罕见的WM与嗜酸性胃肠道疾病先后发生的病例，这带来了诊断和治疗上的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0734/11652698/8ff136eff6ac/IJHOSCR-18-411-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0734/11652698/44338551faba/IJHOSCR-18-411-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0734/11652698/8ff136eff6ac/IJHOSCR-18-411-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0734/11652698/44338551faba/IJHOSCR-18-411-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0734/11652698/8ff136eff6ac/IJHOSCR-18-411-g002.jpg

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本文引用的文献

1
Eosinophilic Gastrointestinal Disorders.嗜酸性粒细胞性胃肠道疾病。
Clin Rev Allergy Immunol. 2019 Oct;57(2):272-285. doi: 10.1007/s12016-019-08732-1.
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MYD88 and CXCR4 Mutation Profiling in Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinaemia.淋巴浆细胞淋巴瘤/华氏巨球蛋白血症中MYD88和CXCR4突变分析
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Novel aspects pertaining to the relationship of Waldenström's macroglobulinemia, IgM monoclonal gammopathy of undetermined significance, polyclonal gammopathy, and hypoglobulinemia.与华氏巨球蛋白血症、意义未明的IgM单克隆丙种球蛋白病、多克隆丙种球蛋白病及低球蛋白血症之间关系相关的新方面。
Clin Lymphoma Myeloma. 2009 Mar;9(1):19-22. doi: 10.3816/CLM.2009.n.003.
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International prognostic scoring system for Waldenstrom macroglobulinemia.华氏巨球蛋白血症国际预后评分系统。
Blood. 2009 Apr 30;113(18):4163-70. doi: 10.1182/blood-2008-08-174961. Epub 2009 Feb 5.
8
Paradoxical increases in serum IgM and viscosity levels following rituximab in Waldenstrom's macroglobulinemia.在华氏巨球蛋白血症中，利妥昔单抗治疗后血清IgM和黏度水平出现反常升高。
Ann Oncol. 2004 Oct;15(10):1481-3. doi: 10.1093/annonc/mdh403.
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