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Combining Antidepressants with β-Blockers: Evidence of a Clinically Significant CYP2D6 Drug Interaction.联合使用抗抑郁药和β受体阻滞剂：临床显著 CYP2D6 药物相互作用的证据。
Pharmacotherapy. 2020 Jun;40(6):507-516. doi: 10.1002/phar.2406. Epub 2020 May 22.
3
A Scoping Review of the Evidence Behind Cytochrome P450 2D6 Isoenzyme Inhibitor Classifications.细胞色素 P450 2D6 同工酶抑制剂分类证据的范围综述。
Clin Pharmacol Ther. 2020 Jul;108(1):116-125. doi: 10.1002/cpt.1768. Epub 2020 Feb 13.
4
Efficacy of Tramadol for Pain Management in Patients Receiving Strong Cytochrome P450 2D6 Inhibitors.曲马多治疗强细胞色素 P450 2D6 抑制剂治疗患者的疼痛管理效果。
Pharmacotherapy. 2019 Jun;39(6):724-729. doi: 10.1002/phar.2269. Epub 2019 May 20.
5
Acute Urinary Retention and Acute Kidney Injury After Duloxetine Treatment: A Rare Case Report.度洛西汀治疗后急性尿潴留和急性肾损伤：一例罕见病例报告
J Clin Psychopharmacol. 2019 May/Jun;39(3):279-281. doi: 10.1097/JCP.0000000000001020.
6
Synergistic effect of polyethylene glycol and superdisintegrant on dissolution rate enhancement of simvastatin in pellet formulation.聚乙二醇和超级崩解剂对辛伐他汀丸剂配方溶出速率的协同增强作用。
Pharm Dev Technol. 2019 Jul;24(6):720-728. doi: 10.1080/10837450.2019.1584632. Epub 2019 Mar 26.
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Differences in Duloxetine Dosing Strategies in Smoking and Nonsmoking Patients: Therapeutic Drug Monitoring Uncovers the Impact on Drug Metabolism.吸烟和非吸烟患者度洛西汀给药策略的差异：治疗药物监测揭示了对药物代谢的影响。
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8
Duloxetine Uses in Patients With Kidney Disease: Different Recommendations From the United States Versus Europe and Canada.度洛西汀在肾病患者中的应用：美国与欧洲及加拿大的不同推荐意见。
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管理合并内科疾病的度洛西汀患者的临床要点。

Clinical pearls for the management of duloxetine patients with medical comorbidities.

作者信息

O'Connell Megan, VandenBerg Amy

机构信息

(Corresponding author) Clinical Pharmacy Specialist, Psychiatry and Neurology, University of Michigan Health, Ann Arbor, Michigan,

Clinical Pharmacy Specialist, Psychiatry and Neurology, University of Michigan Health, Ann Arbor, Michigan; Clinical Associate Professor of Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan.

出版信息

Ment Health Clin. 2024 Dec 2;14(6):313-320. doi: 10.9740/mhc.2024.12.313. eCollection 2024 Dec.

DOI:10.9740/mhc.2024.12.313
PMID:39703684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11616965/
Abstract

The effective use of duloxetine can be complicated by acute kidney injury, acute and/or chronic hepatic dysfunction, dysphagia, enteral nutrition, and common pharmacokinetic interactions. This article aimed to review the pharmacological properties of duloxetine pertinent to its use and to discuss the management of duloxetine in patients with common acute and chronic medical comorbidities. Management strategies based on clinical data and expert opinion are reviewed in 3 patient cases.

摘要

度洛西汀的有效使用可能会因急性肾损伤、急慢性肝功能不全、吞咽困难、肠内营养以及常见的药代动力学相互作用而变得复杂。本文旨在综述度洛西汀与用药相关的药理学特性，并探讨合并常见急慢性内科疾病患者中度洛西汀的管理。通过3例患者病例回顾了基于临床数据和专家意见的管理策略。