Su Ziwei, Li Qilong, Zhang Yiwei, Liu Tong, Lv Kunying, Feng Anni, Yang Yixin, Zhang Yanxin, Wei Zhiming, Sang Xiaoyu, Feng Ying, Chen Ran, Jiang Ning, Chen Qijun
Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China.
Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang 110866, China.
Research (Wash D C). 2024 Dec 19;7:0559. doi: 10.34133/research.0559. eCollection 2024.
Neutrophils are essential in combating invading pathogens such as parasites, but the participation of their subpopulations and mechanisms in resistance to parasite infection are not fully understood. Our study identified a marked increase in Ly6G neutrophils in response to ANKA infection. Depletion of these cells rendered mice more susceptible to infection. Elevated interleukin-17 (IL-17) levels, which increased the Ly6G neutrophil population, were also found to contribute to this protective effect. IL-17 depletion led to reduced neutrophil numbers and increased susceptibility. Furthermore, dihydroartemisinin (DHA) treatment enhanced neutrophil-mediated immune responses through up-regulation of CD18 and CXCR4 factors. These findings revealed key mechanisms of neutrophil and IL-17 interactions in malaria protection and highlighted DHA's potential to promote neutrophil function in combating malaria.
中性粒细胞在对抗诸如寄生虫等入侵病原体方面至关重要，但其亚群的参与情况以及抵抗寄生虫感染的机制尚未完全明确。我们的研究发现，感染ANKA后，Ly6G中性粒细胞显著增加。去除这些细胞会使小鼠更易感染。还发现白细胞介素-17（IL-17）水平升高增加了Ly6G中性粒细胞数量，这也有助于产生这种保护作用。去除IL-17会导致中性粒细胞数量减少且易感性增加。此外，双氢青蒿素（DHA）治疗通过上调CD18和CXCR4因子增强了中性粒细胞介导的免疫反应。这些发现揭示了中性粒细胞与IL-17在疟疾保护中的相互作用关键机制，并突出了DHA在促进中性粒细胞抗疟功能方面的潜力。
