Engku Abd Rahman Engku Nur Syafirah, Irekeola Ahmad Adebayo, Yamin Dina, Elmi Abdirahman Hussein, Chan Yean Yean
Department of Medical Microbiology and Parasitology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
Department of Biological Sciences, Microbiology Unit, College of Natural and Applied Sciences, Summit University Offa, Offa, Kwara, Nigeria.
PeerJ. 2024 Dec 16;12:e18604. doi: 10.7717/peerj.18604. eCollection 2024.
Borderline oxacillin-resistant (BORSA) has been a persistent yet under-researched concern in the realm of antibiotic resistance, characterized by unique resistance mechanisms and potential for severe infections. This systematic review and meta-analysis consolidates data from 29 studies encompassing 18,781 samples, revealing a global BORSA prevalence of 6.6% (95% CI [4.0-10.7]). The highest prevalence was found in animals (46.3%), followed by food (8.9%), and humans (5.1%). Notably, significant regional disparities were observed, with Brazil exhibiting the highest prevalence at 70.0%, while The Netherlands reported just 0.5%. These findings underscore the multifaceted nature of BORSA epidemiology, influenced by local antibiotic usage practices and healthcare infrastructures. The analysis also reveals substantial heterogeneity ( = 96.802%), highlighting the need for improved reporting practices and tailored surveillance protocols that account for the specific contexts of each study. As antibiotic resistance continues to escalate, understanding BORSA's global footprint is crucial for informing targeted interventions and optimizing antibiotic stewardship programs. This study fills critical gaps in current knowledge of BORSA and highlights the need for coordinated efforts among researchers, healthcare providers, and policymakers to develop effective strategies for addressing the rising threat of antibiotic-resistant pathogens like BORSA, including further exploration of its genetic and phenotypic characteristics.
临界耐苯唑西林（BORSA）一直是抗生素耐药领域中一个长期存在但研究不足的问题，其特点是具有独特的耐药机制和引发严重感染的可能性。这项系统评价和荟萃分析整合了来自29项研究的数据，涵盖18781个样本，结果显示全球BORSA患病率为6.6%（95%置信区间[4.0 - 10.7]）。患病率最高的是动物（46.3%），其次是食品（8.9%）和人类（5.1%）。值得注意的是，观察到显著的地区差异，巴西的患病率最高，为70.0%，而荷兰仅报告为0.5%。这些发现强调了BORSA流行病学的多方面性质，受到当地抗生素使用习惯和医疗保健基础设施的影响。分析还揭示了大量的异质性（I² = 96.802%），这突出表明需要改进报告做法，并制定适合具体情况的监测方案，以考虑每项研究的特定背景。随着抗生素耐药性持续升级，了解BORSA在全球的影响范围对于指导有针对性的干预措施和优化抗生素管理计划至关重要。这项研究填补了目前关于BORSA知识的关键空白，并强调研究人员、医疗保健提供者和政策制定者需要共同努力，制定有效的策略来应对像BORSA这样的抗生素耐药病原体日益增加的威胁，包括进一步探索其基因和表型特征。
