Kiran Sumira, Ikram Shuja, Khizar Ahtesham, Iftikhar Muhammad Kaleem, Qadri Haseeb Mehmood, Umer Muhammad Waqas, Anwar Khawar, Bashir Asif
Sumira Kiran, MBBS, MS Assistant Professor Neurosurgery, Department of Neurosurgery Unit-I, Punjab Institute of Neurosciences, Lahore, Pakistan.
Shuja Ikram, MBBS Postgraduate Resident Neurosurgery, Department of Neurosurgery Unit-I, Punjab Institute of Neurosciences, Lahore, Pakistan.
Pak J Med Sci. 2024 Dec;40(12PINS Suppl):S20-S24. doi: 10.12669/pjms.40.12(PINS).11109.
To determine the incidence of postoperative cerebrospinal fluid (CSF) leaks after endoscopic endonasal transsphenoidal surgery (EETS) for pituitary adenomas without sellar floor reconstruction (SFR).
This retrospective observational study was conducted at Department of Neurosurgery, Punjab Institute of Neurosciences (PINS), Lahore, Pakistan from January, 2018 to December, 2022. It is a non-probability based consecutive case series. A total of 316 patients meeting the inclusion criteria were selected.
Among the 316 patients, 102 (32.3%) were male, while 214 (67.7%) were female. Mean age was 40.98 ± 7.8 SD (range 23 to 65 years). Regarding size of pituitary adenomas, 19 (6%) were microadenomas and 297 (94%) were macroadenomas. Overall postoperative CSF (poCSF) leak in our patients was 2.8%. Among cases with poCSF leak, 4 (3.9%) were male and five were female (2.3%) with the P-value of 0.477. Regarding size of pituitary adenomas, only one (5.3%) microadenoma had poCSF leak whereas 8 (2.7%) macroadenomas had poCSF leak with the P-value of 0.432.
Pituitary adenomas can be successfully treated with EETS without SFR in patients who do not experience intraoperative CSF leak.
确定垂体腺瘤经鼻内镜下经蝶窦手术（EETS）且未进行鞍底重建（SFR）后术后脑脊液（CSF）漏的发生率。
本回顾性观察研究于2018年1月至2022年12月在巴基斯坦拉合尔旁遮普神经科学研究所（PINS）神经外科进行。这是一个基于非概率的连续病例系列。共选取了316例符合纳入标准的患者。
316例患者中，男性102例（32.3%），女性214例（67.7%）。平均年龄为40.98±7.8标准差（范围23至65岁）。关于垂体腺瘤的大小，微腺瘤19例（6%），大腺瘤297例（94%）。我们患者的总体术后脑脊液（poCSF）漏发生率为2.8%。在发生poCSF漏的病例中，男性4例（3.9%），女性5例（2.3%），P值为0.477。关于垂体腺瘤的大小，只有1例（5.3%）微腺瘤发生poCSF漏，而8例（2.7%）大腺瘤发生poCSF漏，P值为0.432。
对于术中未发生脑脊液漏的患者，垂体腺瘤可通过不进行鞍底重建的EETS成功治疗。
