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缓释型茶碱制剂导致的致命性过量用药。

Fatal overdose from a sustained-release theophylline preparation.

作者信息

Robertson N J

出版信息

Ann Emerg Med. 1985 Feb;14(2):154-8. doi: 10.1016/s0196-0644(85)81079-9.

DOI:10.1016/s0196-0644(85)81079-9
PMID:3970401
Abstract

A 26-year-old woman ingested approximately 9 g of theophylline (Theodur). She exhibited agitation, generalized seizures, hyperglycemia, hypokalemia, hypomagnesemia, hypophosphatemia, and diuresis. Later in her hospital course rhabdomyolysis, myoglobinuria, and acute renal failure occurred. Hemodialysis was performed to correct electrolyte imbalance. She subsequently died of intractable shock and hyperkalemia. This case illustrates the metabolic abnormalities which may occur with severe theophylline intoxication.

摘要

一名26岁女性摄入了约9克氨茶碱(茶喘平)。她出现了烦躁不安、全身性癫痫发作、高血糖、低钾血症、低镁血症、低磷血症和多尿。在其住院过程后期,发生了横纹肌溶解、肌红蛋白尿和急性肾衰竭。进行了血液透析以纠正电解质失衡。她随后死于顽固性休克和高钾血症。该病例说明了严重氨茶碱中毒可能出现的代谢异常。

相似文献

1
Fatal overdose from a sustained-release theophylline preparation.缓释型茶碱制剂导致的致命性过量用药。
Ann Emerg Med. 1985 Feb;14(2):154-8. doi: 10.1016/s0196-0644(85)81079-9.
2
Pronounced metabolic response to modest theophylline overdose.对适度氨茶碱过量有明显的代谢反应。
Ann Pharmacother. 1994 Feb;28(2):195-6. doi: 10.1177/106002809402800207.
3
Metabolic abnormalities associated with intentional theophylline overdose.与故意过量服用茶碱相关的代谢异常。
Ann Intern Med. 1984 Oct;101(4):457-62. doi: 10.7326/0003-4819-101-4-457.
4
Failure of gastric emptying and charcoal administration in fatal sustained-release theophylline overdose: pharmacobezoar formation.致命性缓释茶碱过量中毒时胃排空失败与给予活性炭的情况:药物性胃石形成
Ann Emerg Med. 1992 Nov;21(11):1388-90. doi: 10.1016/s0196-0644(05)81907-9.
5
[Rhabdomyolysis as a rare complication of theophylline poisoning].[横纹肌溶解症作为茶碱中毒的罕见并发症]
Med Klin (Munich). 2001 Jan 15;96(1):40-4. doi: 10.1007/pl00002151.
6
On-line hemodialysis and hemoperfusion in a girl intoxicated by theophylline.茶碱中毒女孩的在线血液透析和血液灌流
Acta Med Scand. 1988;223(6):565-7. doi: 10.1111/j.0954-6820.1988.tb17697.x.
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Acute renal failure in theophylline poisoning.茶碱中毒所致急性肾衰竭
Neth J Med. 1993 Feb;42(1-2):61-4.
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Concepts and controversies of bronchodilator overdose.支气管扩张剂过量的概念与争议
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[A case of sustained-release theophylline (Theodur)-induced asthma].[一例缓释茶碱(舒弗美)诱发的哮喘]
Nihon Kyobu Shikkan Gakkai Zasshi. 1991 Nov;29(11):1495-8.
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Massive theophylline overdose with atypical metabolic abnormalities.大剂量茶碱过量伴非典型代谢异常。
Clin Chem. 1990 Feb;36(2):398-9.

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Drug-induced hypomagnesaemia : scope and management.药物性低镁血症:范围与管理
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Theophylline poisoning. Pharmacological considerations and clinical management.茶碱中毒。药理学考量与临床处理
Med Toxicol. 1986 May-Jun;1(3):169-91. doi: 10.1007/BF03259836.
3
Adverse reactions and interactions with theophylline.
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