Stegmayr B G
Department of Internal Medicine, University Hospital, Umeå, Sweden.
Acta Med Scand. 1988;223(6):565-7. doi: 10.1111/j.0954-6820.1988.tb17697.x.
In a suicidal attempt, a 15-year-old girl had ingested about 40 g of theophylline from sustained-release preparations. Symptoms of intoxication increased and serum concentrations of theophylline rose from 438 to 1,000 mumol/l. Conservative therapy was also combined by the use of hemodialysis as well as charcoal hemoperfusion on line. Treatment successfully reduced side-effects and S-theophylline within 12 hours and the patient could leave the hospital without residual sequelae. The combination of hemodialysis and hemoperfusion may reduce the risk of hypopotassiemia and hypocalcemia as well as increase in the clearance of the drug.
一名15岁女孩企图自杀，服用了约40克缓释制剂形式的茶碱。中毒症状加重，血清茶碱浓度从438微摩尔/升升至1000微摩尔/升。保守治疗联合了血液透析以及在线血液灌流。治疗成功减轻了副作用，并在12小时内降低了S-茶碱水平，患者得以出院，无残留后遗症。血液透析和血液灌流联合使用可降低低钾血症和低钙血症的风险，并增加药物清除率。
