Knigge Sara, Dogan Günes, Deniz Ezin, Hanke Jasmin, Merzah Ali, Berliner Dominik, Kong Fanwu, Heilmann Torsten, Schmack Bastian, Popov Aron F, Weymann Alexander, Bauersachs Johann, Ruhparwar Arjang, Schmitto Jan D
Department of Cardiac-, Thoracic-, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Department of Cardiology, Hannover Medical School, Hannover, Germany.
Artif Organs. 2025 Mar;49(3):525-531. doi: 10.1111/aor.14933. Epub 2024 Dec 20.
The study assesses the feasibility of the DuoCor BiVAS, a novel biventricular assist system integrating magnetic levitation technology.
In an acute large animal model involving five sheep, each received the DuoCor BiVAS without cardiopulmonary bypass. Hemodynamic and device parameters were monitored continuously for 1-h post-implantation.
Intraoperative implantation was uneventful, demonstrating successful biventricular support with mean blood flows of 5.4 LPM (left) and 5.5 LPM (right). Analysis showed proportional flow rates and relationships between pump speed, flow, and power consumption. No adverse events like thrombus formation, bleeding, stroke, or device failure occurred.
This research underscores the DuoCor BiVAS's potential for severe biventricular heart failure treatment, providing insights into its feasibility and functionality in acute animal models. The findings suggest promising clinical applications, particularly with the system's single driveline design potentially enhancing patient mobilization and quality of life. Further investigations are needed to advance this technology for broader clinical use.
本研究评估了一种集成磁悬浮技术的新型双心室辅助系统DuoCor BiVAS的可行性。
在一个涉及五只绵羊的急性大型动物模型中，每只绵羊在无体外循环的情况下接受了DuoCor BiVAS。植入后连续1小时监测血流动力学和设备参数。
术中植入过程顺利，成功实现双心室支持，左心室平均血流量为5.4升/分钟，右心室平均血流量为5.5升/分钟。分析显示了流量比例以及泵速、流量和功耗之间的关系。未发生血栓形成、出血、中风或设备故障等不良事件。
本研究强调了DuoCor BiVAS在治疗严重双心室心力衰竭方面的潜力，为其在急性动物模型中的可行性和功能提供了见解。研究结果表明其具有良好的临床应用前景，特别是该系统的单驱动线设计可能会提高患者的活动能力和生活质量。需要进一步研究以推动该技术更广泛的临床应用。
