Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Ludwig Boltzmann Institute Cardiovascular Research, Vienna, Austria.
Artif Organs. 2020 Jul;44(7):E251-E262. doi: 10.1111/aor.13638. Epub 2020 Mar 1.
Suction of the left ventricle can lead to potentially life-threatening events in left ventricular assist device (LVAD) patients. With the resolution of currently available clinical LVAD monitoring healthcare professionals are unable to evaluate patients' suction occurrences in detail. This study investigates occurrences and durations of suction events and their associations with tachycardia in stable outpatients. Continuous high-resolution LVAD data from HVAD patients were analyzed in the early outpatient period for 15 days. A validated suction detection from LVAD signals was used. Suction events were evaluated as suction rates, bursts of consecutive suction beats, and clusters of suction beats. The occurrence of tachycardia was analyzed before, during, and after suction clusters. Furthermore, blood work, implant strategy, LVAD speed setting, inflow cannula position, left ventricular diameters, and adverse events were evaluated in these patients. LVAD data of 10 patients was analyzed starting at 78 ± 22 postoperative days. Individuals' highest suction rates per hour resulted in a median of 11% (range 3%-61%). Bursts categorized as consecutive suction beats with n = 2, n = 3-5, n = 6-15, and n > 15 beats were homogenously distributed with 10.3 ± 0.8% among all suction beats. Larger suction bursts were followed by shorter suction-free periods. Tachycardia during suction occurred in 12% of all suction clusters. Significant differences in clinical parameters between individuals with high and low suction rates were only observed in left ventricular end-diastolic and end-systolic diameters (P < .02). Continuous high-resolution LVAD monitoring sheds light on outpatient suction occurrences. Interindividual and intraindividual characteristics of longitudinal suction rates were observed. Longer suction clusters have higher probabilities of tachycardia within the cluster and more severe types of suction waveforms. This work shows the necessity of improved LVAD monitoring and the implementation of an LVAD speed control to reduce suction rates and their concomitant burden on the cardiovascular system.
左心室抽吸可能导致左心室辅助装置 (LVAD) 患者发生潜在危及生命的事件。随着目前可用的临床 LVAD 监测技术的发展,医护人员无法详细评估患者的抽吸事件。本研究旨在探讨稳定门诊患者中抽吸事件的发生和持续时间及其与心动过速的关系。对 HVAD 患者在门诊早期的 15 天内连续的高分辨率 LVAD 数据进行了分析。使用经过验证的 LVAD 信号抽吸检测方法。抽吸事件被评估为抽吸率、连续抽吸搏动的爆发和抽吸搏动的簇。在抽吸簇之前、期间和之后分析心动过速的发生。此外,对这些患者的血液检查、植入策略、LVAD 速度设置、流入套管位置、左心室直径和不良事件进行了评估。对 10 名患者的 LVAD 数据进行了分析,从术后第 78±22 天开始。每个人每小时的最高抽吸率中位数为 11%(范围 3%-61%)。连续抽吸搏动分类为 n=2、n=3-5、n=6-15 和 n>15 个搏动,其在所有抽吸搏动中的比例均为 10.3±0.8%。较大的抽吸搏动后紧接着是较短的抽吸无搏动期。在 12%的抽吸簇中发生了抽吸期间的心动过速。仅在左心室舒张末期和收缩末期直径方面观察到个体间和个体内高和低抽吸率之间的临床参数存在显著差异(P<.02)。连续高分辨率 LVAD 监测揭示了门诊抽吸事件。观察到个体间和个体内纵向抽吸率的特征。较长的抽吸簇在簇内发生心动过速的概率更高,并且抽吸波形的类型更严重。本研究表明需要改进 LVAD 监测并实施 LVAD 速度控制以降低抽吸率及其对心血管系统的负担。