Yin Dongliang, Niu Ruirong, Lu Peilin, Yin Ruilong, Lin Zhiqiang
Department of Hepatobiliary and Pancreatic Surgery, Dongguan People's Hospital, Dongguan, 523059, China.
Department of Neurosurgery, Dongguan People's Hospital, Dongguan, 523059, China.
Discov Oncol. 2024 Dec 20;15(1):815. doi: 10.1007/s12672-024-01660-3.
This study aim is to evaluate the application of stored autologous blood transfusion in liver cancer surgery and explore its impact on postoperative changes in inflammatory factors and liver function recovery.
The study used a control group (CG) design and included 150 patients who underwent liver cancer surgery. While the observation group (OG) got autologous blood that had been preserved, the CG had a standard allogeneic blood transfusion. Examine the variations between the CG and the OG using the following measures: prior to, during, and following surgery contrast MELD score, blood routine indicators, pro-inflammatory cytokine levels.
MELD ratings, IL-1, IL-6, TNF-α levels, and preoperative blood routine indicators did not differ between the observation and CGs (p > 0.05). However, the blood routine indicators in the OG were lower than those in the CG on the first day following surgery (p < 0.05); seven days following surgery, there was no significant difference among the experiment participants (p > 0.05). In the meanwhile, the postoperative OG's levels of IL-1, IL-6, TNF-α, and HAF were lower than those of the CG (p < 0.05). The PVF of the OG was lower than the CG on the first day following surgery (p < 0.05), but on the seventh day following surgery, there was no discernible difference between the experiment's participants (p > 0.05).
The research outcomes showcase that stored autologous blood transfusion can reduce the levels of inflammatory factors after surgery and promote the recovery of liver function;Research suggests important references for further understanding the application and mechanism of stored autologous blood transfusion, and provide a basis for personalized treatment and recovery of liver cancer patients undergoing surgery.
本研究旨在评估储存式自体输血在肝癌手术中的应用，并探讨其对术后炎症因子变化及肝功能恢复的影响。
本研究采用对照组（CG）设计，纳入150例行肝癌手术的患者。观察组（OG）输注保存的自体血，CG组接受标准的异体输血。采用以下指标检查CG组和OG组之间的差异：手术前、手术中和手术后对比终末期肝病模型（MELD）评分、血常规指标、促炎细胞因子水平。
观察组和CG组的MELD评分、白细胞介素-1（IL-1）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平及术前血常规指标无差异（p＞0.05）。然而，术后第1天OG组的血常规指标低于CG组（p＜0.05）；术后7天，实验参与者之间无显著差异（p＞0.05）。同时，术后OG组的IL-1、IL-6、TNF-α和透明质酸（HAF）水平低于CG组（p＜0.05）。术后第1天OG组的门静脉血流速度（PVF）低于CG组（p＜0.05），但术后第7天，实验参与者之间无明显差异（p＞0.05）。
研究结果表明，储存式自体输血可降低术后炎症因子水平，促进肝功能恢复；本研究为进一步了解储存式自体输血的应用及机制提供了重要参考，并为肝癌手术患者的个性化治疗和康复提供了依据。
