He Panpan, Ye Ziliang, Liu Mengyi, Zhang Yuanyuan, Zhou Chun, Zhang Yanjun, Yang Sisi, Qin Xianhui
Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
J Strength Cond Res. 2025 Apr 1;39(4):e589-e597. doi: 10.1519/JSC.0000000000005036. Epub 2024 Dec 19.
He, P, Ye, Z, Liu, M, Zhang, Y, Zhou, C, Zhang, Y, Yang, S, and Qin, X. Associations of handgrip strength, walking pace, and genetic risks with incident arrhythmias. J Strength Cond Res 39(4): e589-e597, 2025-We quantified the associations of handgrip strength and walking pace with incident arrhythmias using Cox proportional hazards models with hazards ratios (HRs). The study included 487,673 subjects, with an average age of 56.4 years, 54.8% female, and free of baseline arrhythmias from the UK Biobank prospective study. Handgrip strength was assessed by a dynamometer. Low handgrip strength was defined as less than 27 kg in men and 16 kg in women. Walking pace was self-reported as slow, average, or brisk. The arrhythmia categories involved incident atrial fibrillation (AF), incident ventricular arrhythmias, and incident bradyarrhythmia, respectively. Over a median follow-up duration of 12.4 years, 28,967 (5.9%), 4,061 (0.8%), and 11,741 (2.4%) subjects developed incident AF, incident ventricular arrhythmias, and incident bradyarrhythmia, respectively. Compared with those with low handgrip strength, the adjusted HRs (95% confidence interval [CI]) of incident AF, ventricular arrhythmias, and bradyarrhythmia in subjects with normal handgrip strength were 0.76 (95% CI: 0.73.-0.79), 0.75 (95% CI: 0.67.-0.84), and 0.80 (95% CI: 0.74.-0.85), respectively. Compared with those with a slow walking pace, subjects with a brisk walking pace had significantly lower risks of incident AF (HR, 0.56; 95% CI: 0.53.-0.58), ventricular arrhythmias (HR, 0.52; 95% CI: 0.45.-0.59), and bradyarrhythmia (HR, 0.63; 95% CI: 0.59.-0.68). In addition, the inverse associations of handgrip strength and walking pace with AF were significantly stronger among those with a lower genetic risk of AF (both p interaction <0.001). In conclusion, handgrip strength and walking pace were inversely associated with incident arrhythmias. The inverse associations for incident AF were stronger in those with a lower genetic risk of AF.
何、P、叶、Z、刘、M、张、Y、周、C、张、Y、杨、S和秦、X。握力、步行速度与遗传风险与心律失常发生的关联。《力量与体能研究杂志》39(4):e589 - e597，2025年。我们使用Cox比例风险模型及风险比（HRs）量化了握力和步行速度与心律失常发生的关联。该研究纳入了487,673名受试者，平均年龄56.4岁，女性占54.8%，来自英国生物银行前瞻性研究且无基线心律失常。握力通过测力计评估。男性握力低定义为小于27千克，女性为小于16千克。步行速度由受试者自我报告为慢、平均或快。心律失常类别分别包括新发房颤（AF）、新发室性心律失常和新发缓慢性心律失常。在中位随访时长12.4年期间，分别有28,967名（5.9%）、4,061名（0.8%）和11,741名（2.4%）受试者发生了新发房颤、新发室性心律失常和新发缓慢性心律失常。与握力低的受试者相比，握力正常的受试者发生房颤、室性心律失常和缓慢性心律失常的校正后HRs（95%置信区间[CI]）分别为0.76（95% CI: 0.73 - 0.79）、0.75（95% CI: 0.67 - 0.84）和0.80（95% CI: 0.74 - 0.85）。与步行速度慢的受试者相比，步行速度快的受试者发生房颤（HR，0.56；95% CI: 0.53 - 0.58）、室性心律失常（HR，0.52；95% CI: 0.45 - 0.59）和缓慢性心律失常（HR，0.63；95% CI: 0.59 - 0.68）的风险显著更低。此外，在房颤遗传风险较低的人群中，握力和步行速度与房颤的负相关更强（两者p交互作用<0.001）。总之，握力和步行速度与心律失常发生呈负相关。在房颤遗传风险较低的人群中，与新发房颤的负相关更强。
