Zureigat Hamzeh, Alshammari Saleh, Alshammari Mohammad, Al-Smadi Mohammed, Al-Sawallah M Mossa
Faculty of Science and Technology, Department of Mathematics, Jadara University, Irbid, Jordan.
Department of Mathematics, College of Science, University of Ha´il, Ha´il, Saudi Arabia.
PLoS One. 2024 Dec 20;19(12):e0303891. doi: 10.1371/journal.pone.0303891. eCollection 2024.
The cancer tumor model serves a s a crucial instrument for understanding the behavior of different cancer tumors. Researchers have employed fractional differential equations to describe these models. In the context of time fractional cancer tumor models, there's a need to introduce fuzzy quantities instead of crisp quantities to accommodate the inherent uncertainty and imprecision in this model, giving rise to a formulation known as fuzzy time fractional cancer tumor models. In this study, we have developed an implicit finite difference method to solve a fuzzy time-fractional cancer tumor model. Instead of utilizing classical time derivatives in fuzzy cancer models, we have examined the effect of employing fuzzy time-fractional derivatives. To assess the stability of our proposed model, we applied the von Neumann method, considering the cancer cell killing rate as time-dependent and utilizing Caputo's derivative for the time-fractional derivative. Additionally, we conducted various numerical experiments to assess the viability of this new approach and explore relevant aspects. Furthermore, our study identified specific needs in researching the cancer tumor model with fuzzy fractional derivative, aiming to enhance our inclusive understanding of tumor behavior by considering diverse fuzzy cases for the model's initial conditions. It was found that the presented approach provides the ability to encompass all scenarios for the fuzzy time fractional cancer tumor model and handle all potential cases specifically focusing on scenarios where the net cell-killing rate is time-dependent.
癌症肿瘤模型是理解不同癌症肿瘤行为的关键工具。研究人员采用分数阶微分方程来描述这些模型。在时间分数阶癌症肿瘤模型的背景下,需要引入模糊量而非清晰量,以适应该模型中固有的不确定性和不精确性,从而产生了一种称为模糊时间分数阶癌症肿瘤模型的表述。在本研究中,我们开发了一种隐式有限差分方法来求解模糊时间分数阶癌症肿瘤模型。在模糊癌症模型中,我们没有使用经典的时间导数,而是研究了采用模糊时间分数阶导数的效果。为了评估我们提出的模型的稳定性,我们应用了冯·诺依曼方法,将癌细胞杀伤率视为与时间相关,并使用卡普托导数来表示时间分数阶导数。此外,我们进行了各种数值实验,以评估这种新方法的可行性并探索相关方面。此外,我们的研究确定了在研究具有模糊分数阶导数的癌症肿瘤模型时的特定需求,旨在通过考虑模型初始条件的各种模糊情况来增强我们对肿瘤行为的全面理解。结果发现,所提出的方法能够涵盖模糊时间分数阶癌症肿瘤模型的所有情况,并特别处理所有潜在情况,尤其关注净细胞杀伤率与时间相关的情况。