文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

2021年和2022年儿童及成人中新型冠状病毒谱系的动态变化

Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022.

作者信息

Soeorg Hiie, Abroi Aare, Päll Taavi, Dotsenko Liidia, Jaaniso Erik, Kaarna Katrin, Lahesaare Andrio, Naaber Paul, Niglas Heiki, Oopkaup Ott Eric, Peterson Hedi, Reisberg Tuuli, Sadikova Olga, Smit Steven, Talas Ulvi Gerst, Avi Radko, Lutsar Irja, Huik Kristi

机构信息

Department of Microbiology, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

Infection, Immunity and Inflammation Research & Teaching Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.

出版信息

PLoS One. 2024 Dec 20;19(12):e0316213. doi: 10.1371/journal.pone.0316213. eCollection 2024.

DOI:10.1371/journal.pone.0316213
PMID:39705295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11661589/
Abstract

PURPOSE: We aimed to describe SARS-CoV-2 lineages and diversity in children and adults in Estonia and similarity to travel-related cases and neighbouring countries. METHODS: SARS-CoV-2 sequences in 2021-2022 from a nationwide study were included. The proportion of predominant lineages in Estonian regions and among travel-related cases was described by multinomial logistic regression. Simpson's indices of diversity were compared using linear regression. Dynamics of Bray-Curtis dissimilarity was described by applying fuzzy clustering to non-metrical dimensional scaling results. RESULTS: A total of 2,630 sequences from children (<15 years) and 23,031 from adults (≥15 years) were included. The increase in the proportion of Alpha/Delta/Omicron BA.1/BA.2 lineages was delayed in smaller regions (by 3.5-27.5 days). The proportion of Alpha/Delta/Omicron BA.1 increased earlier among travel-related (n = 4,654) than non-travel-related cases (10.5 days). Diversity was lower in non-travel-related than travel-related cases until Delta period by 0.066. Dynamics of lineages and diversity were similar in adults and children. Similarity of lineages was delayed compared to Finland during Alpha/Omicron BA.1/BA.2 periods and different from all neighbouring countries during Delta period. CONCLUSION: SARS-CoV-2 lineages in children and adults were similar. Differences between regions and travel-related cases and varying similarity to neighbouring countries suggest the importance of mobility in the spread.

摘要

目的：我们旨在描述爱沙尼亚儿童和成人中新冠病毒（SARS-CoV-2）的谱系和多样性，以及与旅行相关病例和邻国的相似性。 方法：纳入了2021年至2022年一项全国性研究中的SARS-CoV-2序列。通过多项逻辑回归描述了爱沙尼亚各地区以及与旅行相关病例中主要谱系的比例。使用线性回归比较了辛普森多样性指数。通过对非度量多维尺度分析结果应用模糊聚类来描述布雷-柯蒂斯相异度的动态变化。 结果：共纳入了2630条来自儿童（<15岁）的序列和23031条来自成人（≥15岁）的序列。在较小地区，阿尔法/德尔塔/奥密克戎BA.1/BA.2谱系比例的上升延迟（延迟3.5 - 27.5天）。与旅行无关的病例相比，与旅行相关的病例（n = 4654）中阿尔法/德尔塔/奥密克戎BA.1的比例更早上升（早10.5天）。在德尔塔时期之前，与旅行无关的病例的多样性低于与旅行相关的病例，相差0.066。成人和儿童的谱系动态和多样性相似。在阿尔法/奥密克戎BA.1/BA.2时期，与芬兰相比，谱系相似性出现延迟，在德尔塔时期与所有邻国不同。 结论：儿童和成人中的SARS-CoV-2谱系相似。地区与旅行相关病例之间的差异以及与邻国不同的相似性表明流动性在病毒传播中的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd9c/11661589/ae73b6e17b74/pone.0316213.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd9c/11661589/2616235b67fe/pone.0316213.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd9c/11661589/4755f00776b3/pone.0316213.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd9c/11661589/65876b64530e/pone.0316213.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd9c/11661589/0ce599e83411/pone.0316213.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd9c/11661589/ae73b6e17b74/pone.0316213.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd9c/11661589/2616235b67fe/pone.0316213.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd9c/11661589/4755f00776b3/pone.0316213.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd9c/11661589/65876b64530e/pone.0316213.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd9c/11661589/0ce599e83411/pone.0316213.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd9c/11661589/ae73b6e17b74/pone.0316213.g005.jpg

相似文献

[1]
Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022.

PLoS One. 2024-12-20

[2]
SARS-CoV-2 clade dynamics and their associations with hospitalisations during the first two years of the COVID-19 pandemic.

PLoS One. 2024

[3]
Clinical outcomes and phylogenetic analysis in reflection with three predominant clades of SARS-CoV-2 variants.

Eur J Clin Invest. 2023-9

[4]
Emergence and spread of the SARS-CoV-2 omicron (BA.1) variant across Africa: an observational study.

Lancet Glob Health. 2025-2

[5]
Estimated BNT162b2 Vaccine Effectiveness Against Infection With Delta and Omicron Variants Among US Children 5 to 11 Years of Age.

JAMA Netw Open. 2022-12-1

[6]
Clinical profile analysis of SARS-CoV-2 community infections during periods with omicron BA.2, BA.4/5, and XBB dominance in Hong Kong: a prospective cohort study.

Lancet Infect Dis. 2025-3

[7]
Transmission Patterns of Co-Circulation of Omicron Sub-Lineages in Hong Kong SAR, China, a City with Rigorous Social Distancing Measures, in 2022.

Viruses. 2024-6-18

[8]
Acute and Postacute COVID-19 Outcomes Among Immunologically Naive Adults During Delta vs Omicron Waves.

JAMA Netw Open. 2023-2-1

[9]
Omicron Waves in Argentina: Dynamics of SARS-CoV-2 Lineages BA.1, BA.2 and the Emerging BA.2.12.1 and BA.4/BA.5.

Viruses. 2023-1-22

[10]
Introduction and Rapid Spread of SARS-CoV-2 Omicron Variant and Dynamics of BA.1 and BA.1.1 Sublineages, Finland, December 2021.

Emerg Infect Dis. 2022-6

引用本文的文献

[1]
The effect of policy measures, school holidays and travel on the incidence of SARS-CoV-2 infection in children and adults in Estonia from 2021 to 2022.

PLoS One. 2025-7-3

本文引用的文献

[1]
Susceptibility and infectiousness of SARS-CoV-2 in children versus adults, by variant (wild-type, alpha, delta): A systematic review and meta-analysis of household contact studies.

PLoS One. 2024

[2]
Co-detection of respiratory pathogens among ILI patients: characterization of samples collected during the 2018/19 and 2019/20 pre-pandemic seasons.

BMC Infect Dis. 2024-8-29

[3]
SARS-CoV-2 clade dynamics and their associations with hospitalisations during the first two years of the COVID-19 pandemic.

PLoS One. 2024

[4]
Epidemiology of the SARS-CoV-2 Omicron Variant Emergence in the Southeast Brazilian Population.

Microorganisms. 2024-2-23

[5]
Dynamic of SARS-CoV-2 variants circulation in Tunisian pediatric population, during successive waves, from March 2020 to September 2022.

Virus Res. 2024-6

[6]
Age-specific transmission dynamics of SARS-CoV-2 during the first 2 years of the pandemic.

PNAS Nexus. 2024-1-31

[7]
Rural populations facilitated early SARS-CoV-2 evolution and transmission in Missouri, USA.

Npj Viruses. 2023

[8]
Spatiotemporal evolution of SARS-CoV-2 in the Bangkok metropolitan region, Thailand, 2020-2022: implications for future outbreak preparedness.

Microb Genom. 2023-12

[9]
LMdist: Local Manifold distance accurately measures beta diversity in ecological gradients.

Bioinformatics. 2023-12-1

[10]
SARS-CoV-2 variants of concern in children and adolescents with COVID-19: a systematic review.

BMJ Open. 2023-10-9

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索