孕期HIV血清转化后及时启动孕产妇抗逆转录病毒疗法可有效预防垂直传播及其他不良婴儿结局。
Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes.
作者信息
Sundar Kavya G, Yang Lanbo Z, Cambou Mary C, Varella Ivana R S, Melo Marineide G, Segura Eddy R, Ziegler Ângela P, Santos Breno R, Nielsen-Saines Karin
机构信息
From Department of Obstetrics and Gynecology, SUNY Downstate Health Sciences University, Brooklyn, New York.
Department of Obstetrics and Gynecology, Tulane University School of Medicine, New Orleans, Louisiana.
出版信息
Pediatr Infect Dis J. 2025 Jan 1;44(1):40-43. doi: 10.1097/INF.0000000000004562. Epub 2024 Oct 10.
Abstract
From January 2008 to December 2018, 1348 HIV-exposed infants were born in Porto Alegre, Brazil; 18.8% had adverse infant outcomes (AIO) including vertical transmission (1.9%), stillbirth/neonatal death (4.0%) and loss to follow-up before HIV diagnosis (12.9%). Timing of maternal HIV diagnosis was not associated with AIO but absent antiretroviral therapy use was. Lack of maternal antiretroviral therapy use is a significant risk factor for AIO.
摘要
2008年1月至2018年12月，巴西阿雷格里港有1348名暴露于HIV的婴儿出生；18.8%的婴儿出现不良结局（AIO），包括垂直传播（1.9%）、死产/新生儿死亡（4.0%）以及在HIV诊断前失访（12.9%）。母亲HIV诊断时间与AIO无关，但未使用抗逆转录病毒疗法与之相关。母亲未使用抗逆转录病毒疗法是AIO的一个重要危险因素。
相似文献
1
Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes.孕期HIV血清转化后及时启动孕产妇抗逆转录病毒疗法可有效预防垂直传播及其他不良婴儿结局。
Pediatr Infect Dis J. 2025 Jan 1;44(1):40-43. doi: 10.1097/INF.0000000000004562. Epub 2024 Oct 10.
2
Antiretroviral use during pregnancy for treatment or prophylaxis.妊娠期抗逆转录病毒治疗或预防应用。
Expert Opin Pharmacother. 2011 Aug;12(12):1875-85. doi: 10.1517/14656566.2011.584062. Epub 2011 May 3.
3
Pregnancy and infant outcomes among HIV-infected women taking long-term ART with and without tenofovir in the DART trial.在 DART 试验中，接受长期 ART 治疗且有和无替诺福韦的 HIV 感染妇女的妊娠和婴儿结局。
PLoS Med. 2012;9(5):e1001217. doi: 10.1371/journal.pmed.1001217. Epub 2012 May 15.
4
Hematologic and hepatic toxicities associated with antenatal and postnatal exposure to maternal highly active antiretroviral therapy among infants.婴儿产前和产后接触母体高效抗逆转录病毒疗法相关的血液学和肝脏毒性。
AIDS. 2008 Aug 20;22(13):1633-40. doi: 10.1097/QAD.0b013e328307a029.
5
Antiretroviral drugs for preventing mother-to-child transmission of HIV in sub-Saharan Africa: balancing efficacy and infant toxicity.撒哈拉以南非洲地区用于预防母婴传播艾滋病毒的抗逆转录病毒药物：平衡疗效与婴儿毒性
AIDS. 2008 Nov 12;22(17):2359-69. doi: 10.1097/QAD.0b013e3283189bd7.
6
Factors associated with vertical transmission of HIV in the Western Cape, South Africa: a retrospective cohort analysis.南非西开普省与 HIV 垂直传播相关的因素：一项回顾性队列分析。
J Int AIDS Soc. 2024 Mar;27(3):e26235. doi: 10.1002/jia2.26235.
7
Declines in low birth weight and preterm birth among infants who were born to HIV-infected women during an era of increased use of maternal antiretroviral drugs: Pediatric Spectrum of HIV Disease, 1989-2004.在孕产妇抗逆转录病毒药物使用增加的时期，感染艾滋病毒的妇女所生婴儿的低出生体重和早产情况有所下降：1989 - 2004年儿童艾滋病毒疾病谱
Pediatrics. 2007 Apr;119(4):e900-6. doi: 10.1542/peds.2006-1123. Epub 2007 Mar 12.
8
[HIV+ pregnant woman and exposed children: epidemiological study on compulsory notification].[感染艾滋病毒的孕妇及受感染儿童：强制通报的流行病学研究]
Rev Gaucha Enferm. 2007 Dec;28(4):505-11.
9
Management of Infants Born to Mothers with HIV Infection.HIV 感染母亲所生婴儿的管理。
Am Fam Physician. 2021 Jul 1;104(1):58-62.
10
[Timely implementation of interventions to reduce vertical HIV transmission: a successful experience in Brazil].[及时实施减少艾滋病毒垂直传播的干预措施：巴西的成功经验]
Rev Panam Salud Publica. 2007 Jun;21(6):357-64. doi: 10.1590/s1020-49892007000500003.
本文引用的文献
1
Patterns of pregnancy loss among women living with and without HIV in Brazil, 2008-2018.2008 - 2018年巴西感染和未感染艾滋病毒妇女的流产模式
AJOG Glob Rep. 2022 Oct 17;2(4):100121. doi: 10.1016/j.xagr.2022.100121. eCollection 2022 Nov.
2
Maternal HIV and syphilis are not syndemic in Brazil: Hot spot analysis of the two epidemics.巴西的母婴艾滋病毒和梅毒并非共同流行：对这两种传染病的热点分析。
PLoS One. 2021 Aug 3;16(8):e0255590. doi: 10.1371/journal.pone.0255590. eCollection 2021.
3
Persistent Immune Activation in Human Immunodeficiency Virus-Infected Pregnant Women Starting Combination Antiretroviral Therapy After Conception.感染人类免疫缺陷病毒的孕妇在受孕后开始联合抗逆转录病毒治疗时持续的免疫激活。
J Infect Dis. 2022 Apr 1;225(7):1162-1167. doi: 10.1093/infdis/jiab095.
4
Brazil's unified health system: the first 30 years and prospects for the future.巴西的统一卫生系统：过去 30 年的发展及未来展望。
Lancet. 2019 Jul 27;394(10195):345-356. doi: 10.1016/S0140-6736(19)31243-7. Epub 2019 Jul 11.
5
Impact of Maternal HIV Seroconversion during Pregnancy on Early Mother to Child Transmission of HIV (MTCT) Measured at 4-8 Weeks Postpartum in South Africa 2011-2012: A National Population-Based Evaluation.2011 - 2012年南非孕期孕产妇HIV血清阳转对产后4 - 8周测量的早期母婴传播HIV（MTCT）的影响：一项基于全国人口的评估。
PLoS One. 2015 May 5;10(5):e0125525. doi: 10.1371/journal.pone.0125525. eCollection 2015.
6
A Study of Effects of MultiCollinearity in the Multivariable Analysis.多变量分析中多重共线性影响的研究
Int J Appl Sci Technol. 2014 Oct;4(5):9-19.
7
Three postpartum antiretroviral regimens to prevent intrapartum HIV infection.三种产后抗逆转录病毒方案预防围产期 HIV 感染。
N Engl J Med. 2012 Jun 21;366(25):2368-79. doi: 10.1056/NEJMoa1108275.
8
Extended antenatal use of triple antiretroviral therapy for prevention of mother-to-child transmission of HIV-1 correlates with favorable pregnancy outcomes.延长产前三联抗逆转录病毒疗法用于预防 HIV-1 母婴传播与良好的妊娠结局相关。
AIDS. 2011 Aug 24;25(13):1611-8. doi: 10.1097/QAD.0b013e3283493ed0.
Zotero 插件