Wang Kun, Yi Bin
Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Medicine (Baltimore). 2024 Dec 20;103(51):e40999. doi: 10.1097/MD.0000000000040999.
Automated serum index is widely used in biochemical testing, enabling the observation of sample characteristics to a certain extent. The differences between serum lipemia index and sample characteristics can, to a certain extent, facilitate early detection of certain diseases.
This is a case report of an elderly patient who was admitted to cardiology outpatient clinic due to dizziness.
Basic tests were normal, but hidden lab tests found abnormal serum index. After discussion, further tests showed high immunoglobulin levels.
We performed a lymph node color Doppler ultrasound, blood light chain determination, blood immunization fixed electrophoresis, and urine immunofixation electrophoresis detection. Flow cytometry (lymphoma), FISH (MM + IGH) and MYD88 were detected.
Consequently, the patient was advised to be transferred to the hematology department and was ultimately diagnosed with Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia.
This case was facilitated by the early detection of discrepancies between lipemia indices and sample appearance despite normal examination results. Additionally, close collaboration between clinical laboratory technicians and clinicians facilitated the uncovering of subtle early disease changes, thereby aiding in precise diagnoses.
自动血清指数在生化检测中被广泛应用，能在一定程度上观察样本特征。血清脂血指数与样本特征之间的差异在一定程度上有助于某些疾病的早期检测。
这是一例老年患者的病例报告，该患者因头晕入住心内科门诊。
基础检查正常，但隐蔽的实验室检查发现血清指数异常。经讨论，进一步检查显示免疫球蛋白水平升高。
我们进行了淋巴结彩色多普勒超声、血轻链测定、血液免疫固定电泳和尿液免疫固定电泳检测。检测了流式细胞术（淋巴瘤）、荧光原位杂交（MM + IGH）和MYD88。
因此，建议患者转至血液科，最终被诊断为淋巴浆细胞淋巴瘤/华氏巨球蛋白血症。
尽管检查结果正常，但该病例因早期发现脂血指数与样本外观之间的差异而得到推动。此外，临床实验室技术人员与临床医生之间的密切合作有助于发现细微的早期疾病变化，从而有助于精确诊断。
