Wang Nan, Lv Xiaorong, Wang Peihua, Huang Xiao, Liu Luping, Zhu Ju, Nie Fang
Ultrasound Medical Center, Lanzhou University Second Hospital, Gansu Province Clinical Research Center for Ultrasonography, Gansu Province Medical Engineering Research Center for Intelligence Ultrasound, Lanzhou.
Med Ultrason. 2025 Jun 16;27(2):135-142. doi: 10.11152/mu-4466. Epub 2024 Dec 19.
To investigate the diagnostic value of ultrasound features with dual-phenotype hepatocellular carcinoma (DPHCC). Material and methods: A retrospective analysis was conducted on patients diagnosed with hepatocellular carcinoma (HCC) confirmed by pathology results from October 2016 to December 2023. Patients were categorized into DPHCC and non-DPHCC (NDPHCC) groups based on immunohistochemical findings. Clinical baseline characteristics and ultrasound features were compared between these groups. Multivariable logistic regression was employed to identify predictive factors. A logisticregression model and nomogram were developed to predict DPHCC.
This study included 219 HCC patients (average age: 55.84±9.00, 173 males), with 61 cases of DPHCC and 158 cases of NDPHCC. The results of multivariate logistic regression indicated that halo sign (OR=1.93, p=0.049), PVP hypo-enhancement (OR=2.73, p=0.002) and nodule-in-nodule sign (OR=4.23, p=0.003) were independent predictors of DPHCC. The model's AUC value was 0.73 (95%CI: 0.65-0.80). The calibration curve displayed good predictive accuracy.
Ultrasound features, including CEUS, may provide additional information for the non-invasive diagnosis of DPHCC.
探讨双表型肝细胞癌（DPHCC）超声特征的诊断价值。
对2016年10月至2023年12月经病理结果确诊为肝细胞癌（HCC）的患者进行回顾性分析。根据免疫组化结果将患者分为DPHCC组和非DPHCC（NDPHCC）组。比较两组的临床基线特征和超声特征。采用多变量逻辑回归确定预测因素。建立逻辑回归模型和列线图预测DPHCC。
本研究纳入219例HCC患者（平均年龄：55.84±9.00，男性173例），其中DPHCC 61例，NDPHCC 158例。多变量逻辑回归结果显示，晕环征（OR=1.93，p=0.049）、门静脉期低增强（OR=2.73，p=0.002）和结节中结节征（OR=4.23，p=0.003）是DPHCC的独立预测因素。模型的AUC值为0.73（95%CI：0.65-0.80）。校准曲线显示出良好的预测准确性。
包括超声造影在内的超声特征可为DPHCC的无创诊断提供额外信息。
