Turakainen H, Välimäki M, Penttinen R
Arch Dermatol Res. 1985;277(1):55-9. doi: 10.1007/BF00406481.
A patient is described with typical skin lesions of lichen myxedematosus and IgG-type lambda paraproteinemia. Fibroblasts cultured from the skin of the patient and from the skin of control persons were used to study glycosaminoglycan and collagen synthesis; the cultures were labelled with 3H-glucosamine and 3H-proline, respectively. Fibroblasts from the patient grew to a cell density which was lower than that of the control fibroblasts. The production of glycosaminoglycans was increased in lichen myxedematosus cultures, so that the ratio of hyaluronic acid to sulphated glucosaminoglycans was higher in the patient's cultures than in control cultures. Collagen production in the patient's cultures was about half of that in control cultures, whereas the ratio of type III to type I collagen was normal.
描述了一名患有黏液性水肿性苔藓典型皮肤病变和IgG型λ副蛋白血症的患者。从该患者皮肤和对照者皮肤培养的成纤维细胞用于研究糖胺聚糖和胶原蛋白的合成；培养物分别用3H-葡萄糖胺和3H-脯氨酸标记。患者的成纤维细胞生长至低于对照成纤维细胞的细胞密度。黏液性水肿性苔藓培养物中糖胺聚糖的产生增加，因此患者培养物中透明质酸与硫酸化糖胺聚糖的比率高于对照培养物。患者培养物中的胶原蛋白产生约为对照培养物的一半，而III型与I型胶原蛋白的比率正常。
