Xu Jun, Zhao Xingyu, Lei Zhenzhen, Jia Huimin, He Haolong, Gong Genghao, Wang Jing, Wang Tiegang
School of Textile Science and Engineering, Tiangong University, 399 Binshui West Road, Tianjin 300387, People's Republic of China.
Key Laboratory of Advanced Textile Composite materials, Ministry of Education, Tiangong University, 399 Binshui West Road, Tianjin 300387, People's Republic of China.
Biomed Mater. 2025 Jan 7;20(1). doi: 10.1088/1748-605X/ada23d.
Medical antibacterial textiles play a vital role in tackling the issue of bacterial infection. Traditional surgical sutures face significant challenges due to wound infection caused by bacteria and breakage and scars caused by poor suture strength. Therefore, a new antibacterial and high-strength suture preparation strategy with wide clinical applicability was highly desired. In this study, a biodegradable quaternary ammonium salt (QAS)/polylactic acid (PLA) core-spun yarn with excellent antibacterial and mechanical properties was prepared by conjugated electrospinning technology combined with the braiding process. The antibacterial test results revealed the best overall performance of the PLA micro/nanofiber core-spun yarn with 0.3 wt% QAS antibacterial agent. The antibacterial rate againstandwas 94.49% and 94.00%, respectively, which could effectively solve the problem of wound infection caused by bacteria. In addition, we used the diamond-braided structure to address the poor strength and fragility of the traditional suture strength. The braiding angle of 30° and 45° could effectively enhance the mechanical properties of the yarn, and the breaking strength was also in line with the industry standard. The study proposed that the degradable QAS/PLA micro/nanofiber core-spun yarn, due to its excellent antibacterial and mechanical properties, could find application in medical protection. This provided a new avenue for research into new antibacterial surgical sutures.
医用抗菌纺织品在解决细菌感染问题方面发挥着至关重要的作用。传统外科缝线面临着重大挑战,因为细菌会导致伤口感染,而且缝线强度不佳会导致断裂和留下疤痕。因此,迫切需要一种具有广泛临床适用性的新型抗菌高强度缝线制备策略。在本研究中,通过共轭静电纺丝技术结合编织工艺制备了一种具有优异抗菌和机械性能的可生物降解季铵盐(QAS)/聚乳酸(PLA)包芯纱。抗菌测试结果表明,含0.3 wt% QAS抗菌剂的PLA微/纳米纤维包芯纱整体性能最佳。其对大肠杆菌和金黄色葡萄球菌的抗菌率分别为94.49%和94.00%,能够有效解决细菌引起的伤口感染问题。此外,我们采用菱形编织结构来解决传统缝线强度差和易断裂的问题。30°和45°的编织角度能够有效提高纱线的机械性能,其断裂强度也符合行业标准。该研究表明,可降解的QAS/PLA微/纳米纤维包芯纱因其优异的抗菌和机械性能,可应用于医疗防护领域。这为新型抗菌外科缝线的研究提供了一条新途径。