大胆探索：靶向Gasdermin D的新方法。
D-aring to explore: New approaches to gasdermin D targeting.
作者信息
Wang Lei, Zhou Wen
机构信息
Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China; Shenzhen Key Laboratory of Biomolecular Assembling and Regulation, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
出版信息
Cell Chem Biol. 2024 Dec 19;31(12):2015-2017. doi: 10.1016/j.chembiol.2024.11.006.
Novel inhibitors of pyroptosis promise breakthroughs in treating inflammatory diseases and malignant tumors. In this issue of Cell Chemical Biology, Hu et al. identify two repurposed drugs that selectively target gasdermin D (GSDMD) oligomers, effectively suppressing pyroptosis while reducing off-target effects typical of cysteine-based inhibitors.
新型细胞焦亡抑制剂有望在治疗炎症性疾病和恶性肿瘤方面取得突破。在本期《细胞化学生物学》中，胡等人鉴定出两种重新利用的药物，它们选择性靶向gasdermin D（GSDMD）寡聚体，有效抑制细胞焦亡，同时减少基于半胱氨酸的抑制剂常见的脱靶效应。
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