Wei N, Foon K A
Arch Intern Med. 1985 Jan;145(1):139-40.
A 44-year-old man had mycosis fungoides and generalized plaque disease involving 80% of his skin surface with diffuse lymphadenopathy and alopecia of the scalp and groin. In addition, distal to the wrist, there were sclerodermatous changes involving the skin of the hands with associated sclerodactyly of all digits with loss of normal palmar creases. There were no subungual telangiectasis or digital ulcers. The changes in the hand that occurred in this case, no doubt arose as a result of the patient's neoplasm. Abnormalities of collagen biosynthesis and degradation probably occur with mycosis fungoides as a result of the extensive infiltration of the epidermis and dermis with malignant cells. To our knowledge, the association of sclerodactyly with mycosis fungoides has not been previously reported.
一名44岁男性患有蕈样肉芽肿和泛发性斑块病，累及80%的皮肤表面，伴有弥漫性淋巴结病以及头皮和腹股沟脱发。此外，在手腕远端，手部皮肤出现硬皮病样改变，所有手指均伴有指硬化，掌纹消失。未见甲下毛细血管扩张或指端溃疡。该病例中手部出现的这些改变无疑是由患者的肿瘤引起的。由于恶性细胞广泛浸润表皮和真皮，蕈样肉芽肿可能会出现胶原生物合成和降解异常。据我们所知，指硬化与蕈样肉芽肿的关联此前尚未见报道。
